Matches in SemOpenAlex for { <https://semopenalex.org/work/W1453995107> ?p ?o ?g. }
- W1453995107 endingPage "9" @default.
- W1453995107 startingPage "1" @default.
- W1453995107 abstract "Advances in the diagnosis and treatment of tumors by surgery, chemotherapy, biotherapy, radiotherapy and other modalities have increased the survival of cancer patients over the last 20 years. As a consequence, bone now represents the third most common site of metastatic involvement after the lung and liver. Approximately 20-25% of patients with neoplastic disease develop clinically evident bone metastases (BMs) during the natural course of their illness, with a further 50% of such lesions being identified during autopsy. BMs are the major cause of morbidity in cancer patients because of their epidemiological and clinical impact. Pain is the most frequent symptom in about 75% of patients but other serious complications can also occur, such as pathological fractures, spinal cord compression, hypercalcemia and bone marrow suppression. These complications worsen the patient's general condition and reduce patients' mobility, facilitating the development of lung infections, skin ulcers, deep vein thrombosis, etc., and ultimately reducing prognosis and quality of life. The frequency of serious complications depends on the site and type of lesions and the treatment administered. Over the last 10 years, the introduction of bisphosphonates for the treatment of patients with BMs has led to a marked decrease in the frequency of complications, thus improving quality of life and clinical outcome. Furthermore, progress in understanding the pathophysiology of bone metastases has resulted in the development of new bone-targeted molecules such as denosumab. We therefore felt it would be useful to report on the epidemiological, clinical and economic impact of bone disease in a cancer setting." @default.
- W1453995107 created "2016-06-24" @default.
- W1453995107 creator A5006629788 @default.
- W1453995107 creator A5015241599 @default.
- W1453995107 creator A5050243008 @default.
- W1453995107 creator A5074441183 @default.
- W1453995107 creator A5075055655 @default.
- W1453995107 date "2013-04-04" @default.
- W1453995107 modified "2023-10-17" @default.
- W1453995107 title "Metastatic bone disease in the era of bone-targeted therapy: clinical impact." @default.
- W1453995107 cites W106479996 @default.
- W1453995107 cites W1088362621 @default.
- W1453995107 cites W1492148688 @default.
- W1453995107 cites W1596597141 @default.
- W1453995107 cites W1597177264 @default.
- W1453995107 cites W170508594 @default.
- W1453995107 cites W1775601743 @default.
- W1453995107 cites W1800396987 @default.
- W1453995107 cites W1870076918 @default.
- W1453995107 cites W1897048475 @default.
- W1453995107 cites W1951349736 @default.
- W1453995107 cites W1965963242 @default.
- W1453995107 cites W1971890396 @default.
- W1453995107 cites W1972544033 @default.
- W1453995107 cites W1973142147 @default.
- W1453995107 cites W1974562009 @default.
- W1453995107 cites W1978528349 @default.
- W1453995107 cites W1980616114 @default.
- W1453995107 cites W1982915376 @default.
- W1453995107 cites W1984505642 @default.
- W1453995107 cites W1989194555 @default.
- W1453995107 cites W1990907410 @default.
- W1453995107 cites W1995140356 @default.
- W1453995107 cites W2001747006 @default.
- W1453995107 cites W2005124988 @default.
- W1453995107 cites W2006495870 @default.
- W1453995107 cites W2009441800 @default.
- W1453995107 cites W2009529772 @default.
- W1453995107 cites W2011926580 @default.
- W1453995107 cites W2013284147 @default.
- W1453995107 cites W2018584397 @default.
- W1453995107 cites W2018806950 @default.
- W1453995107 cites W2022098162 @default.
- W1453995107 cites W2030399537 @default.
- W1453995107 cites W2036988592 @default.
- W1453995107 cites W2038484874 @default.
- W1453995107 cites W2047651327 @default.
- W1453995107 cites W2048299560 @default.
- W1453995107 cites W2050358330 @default.
- W1453995107 cites W2050869279 @default.
- W1453995107 cites W2053662837 @default.
- W1453995107 cites W2054351138 @default.
- W1453995107 cites W2056563105 @default.
- W1453995107 cites W2057772566 @default.
- W1453995107 cites W2058532462 @default.
- W1453995107 cites W2060719489 @default.
- W1453995107 cites W2065466740 @default.
- W1453995107 cites W2069129583 @default.
- W1453995107 cites W2074461356 @default.
- W1453995107 cites W2075843463 @default.
- W1453995107 cites W2076942719 @default.
- W1453995107 cites W2077073060 @default.
- W1453995107 cites W2078831902 @default.
- W1453995107 cites W2083163604 @default.
- W1453995107 cites W2092177321 @default.
- W1453995107 cites W2092501833 @default.
- W1453995107 cites W2093252878 @default.
- W1453995107 cites W2093877466 @default.
- W1453995107 cites W2102969047 @default.
- W1453995107 cites W2103164850 @default.
- W1453995107 cites W2103638671 @default.
- W1453995107 cites W2103675786 @default.
- W1453995107 cites W2103891355 @default.
- W1453995107 cites W2104206635 @default.
- W1453995107 cites W2104302044 @default.
- W1453995107 cites W2109333569 @default.
- W1453995107 cites W2119263434 @default.
- W1453995107 cites W2122257179 @default.
- W1453995107 cites W2123450431 @default.
- W1453995107 cites W2137985394 @default.
- W1453995107 cites W2139860898 @default.
- W1453995107 cites W2142914486 @default.
- W1453995107 cites W2145559849 @default.
- W1453995107 cites W2148096512 @default.
- W1453995107 cites W2149775776 @default.
- W1453995107 cites W2153430886 @default.
- W1453995107 cites W2154028327 @default.
- W1453995107 cites W2161962336 @default.
- W1453995107 cites W2162296777 @default.
- W1453995107 cites W2162638249 @default.
- W1453995107 cites W2165011173 @default.
- W1453995107 cites W2167372685 @default.
- W1453995107 cites W2168231864 @default.
- W1453995107 cites W2169061127 @default.
- W1453995107 cites W2170309090 @default.
- W1453995107 cites W2180615502 @default.
- W1453995107 cites W2263254645 @default.
- W1453995107 cites W2312063475 @default.