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- W145422829 abstract "Four-week-old Wistar male rats were given distilled watered ad libitum containing 0, 3, 6, 12, and 25 ppm F- as NaF. At the end of 20 months, morphological changes and endocrinological data on the thyroid gland in these animals were studied. Hyperplastic nodules consisting of thyroid parafollicular cells (C cells) were observed in the experimental animals receiving F-. Both calcitonin and characteristic secretory granules were detected in the cytoplasms of these hyperplastic cells. The striking increase of serum calcitonin level seen in rats with hyperplasia of parafollicular cells substantiated the morphological changes. The thyroid follicles of the experimental animals were larger than those of the controls, although the differences were not highly significant." @default.
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- W145422829 date "1986-01-01" @default.
- W145422829 modified "2023-09-23" @default.
- W145422829 title "Effects of Long Term, Low Dose Ingestion of Fluoride on the Thyroid Gland in Rats" @default.
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- W145422829 doi "https://doi.org/10.1016/s0166-1116(08)71856-9" @default.
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