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- W1454578587 abstract "Objective To investigate the frequency of CD4+CD25+ regulatory T cells and its clinical significance in the peripheral blood of the patients with hepatocellular carcinoma(HCC).Methods Flow cytometer was used to analyze the frequency of regulatory T cell(Treg) in peripheral blood mononuclear cells(PBMC)from both 34 patients with HCC and 30 normal donors.The MTT method was used to observe changes in PBMC proliferative function.Results The frequency of CD4+CD25high regulatory T cells in the peripheral blood of hepatocellular carcinoma patients was higher than that in the control group(P 0.01).The levels of Tregs in peripheral blood were correlated with disease progression in HCC patients.The proliferative function of PBMC in patients with hepatocellular carcinoma was decreased(P 0.01).Conclusion The decreased proliferative function of PBMC and the increased frequency of regulatory T cells in patients with hepatocellular carcinoma may be one of the mechanisms that immune function was impaired in patients with HCC." @default.
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- W1454578587 date "2009-01-01" @default.
- W1454578587 modified "2023-09-26" @default.
- W1454578587 title "Expression of peripheral blood CD4+CD25high Treg subset in patients with hepatocellular carcinoma and its implication." @default.
- W1454578587 hasPublicationYear "2009" @default.
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