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• W1454624246 startingPage "11875" @default.
• W1454624246 abstract "The health risk of inhalation exposure to polychlorinated biphenyls (PCB) cannot be assessed with high confidence due to the lack of rigorous inhalation studies. One uncertainty rests on exposure regimen, as whole-body exposure systems allow oral PCB intake that confounds the exposure. We conducted contemporaneous PCB inhalation exposures with whole-body and nose-only exposure methods. Female Sprague–Dawley rats were concurrently exposed to vapor-phase PCBs (533 ± 93 μg/m3) generated from PCB11-supplemented Chicago Air Mixture resembling the Chicago airshed, 4 h/day, 6 days/week, for 4 weeks. Congener-specific analysis showed 1.5-fold higher ∑PCBs in the lungs of nose-only exposed than the whole-body exposed animals (p = 0.0024). Higher ∑PCB concentrations were also found in the sera, livers, brains, and adipose tissue of nose-only exposed animals (1.1–1.5-fold), but these increases were not statistically significant. Congener profiles of five tissue types were dominated by PCB 28/31 and higher-chlorinated congeners in both groups reflecting rapid metabolism of other lower-chlorinated PCBs. No toxicity was seen regarding metabolic enzyme expression, glutathione, or histopathology. However, diminished weight gain and reduced plasma total thyroxine levels were found in both groups compared with controls, after exposure to 76 μg/m3 ∑PCBs as adjusted for continuous exposure. Hepatic lipid peroxidation was also elevated in the nose-only group. Our study shows that prolonged nose-only exposure was well-tolerated and eliminated the need for housing animals outside the vivarium, thus was preferred for long-term PCB inhalation studies." @default.
• W1454624246 created "2016-06-24" @default.
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• W1454624246 date "2015-09-22" @default.
• W1454624246 modified "2023-10-16" @default.
• W1454624246 title "Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens" @default.
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• W1454624246 doi "https://doi.org/10.1021/acs.est.5b02865" @default.
• W1454624246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4711378" @default.
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• W1454624246 hasPublicationYear "2015" @default.
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