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- W1454650431 abstract "The cardiovascular protective benefits of omega 3 polyunsaturated fatty acids are derived, in part, from cytochrome P450-generated vasodilatory epoxyeicosatetraenoic (EEQ) and epoxydocosapentaenoic (EDP) acids. However, the potencies and mechanisms that mediate this vasodilation have not been fully elucidated. Thus, our study objectives were to compare the potencies of EEQs and EDPs to arachidonic acid (20:4n-6)-derived epoxyeicosatrienoic acids (EETs) and to elucidate the degree to which vasodilation was mediated via potassium channels. Using a wire myograph mouse thoracic aortic rings were preconstricted with U46619 (TP receptor agonist) and dose-dependent relaxation was assessed to R,S and S,R enantiomers of 17,18-EEQ and 19,20-EDP; and to 11,12-EET and 14,15-EET. In addition, studies with EEQs and EDPs were conducted in the presence of iberiotoxin (IBX, BK-channel inhibitor), tetraphenylphosphonium (TPP, K-ATP channel inhibitor), and glibenclamide (GBN, K-ATP channel inhibitor and TP receptor antagonist). The EEQ and EDP enantiomers were significantly more potent (log EC50, -11.3 to -11.8 ±0.2 M) than the EETs (log EC50, -8.0±0.1 M). In addition, TPP exhibited the greatest inhibition of relaxation of the EEQ and EDP enantiomers, ranging from 57-100%, while IBX inhibited 20-50% and GBN inhibited 0-64% depending on the enantiomer. These data demonstrate that epoxide metabolites of omega-3 PUFAs are more potent vasodilators than EETs in some vascular beds and that they mediate a significant portion of vasodilation via potassium channels." @default.
- W1454650431 created "2016-06-24" @default.
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- W1454650431 date "2015-04-01" @default.
- W1454650431 modified "2023-09-27" @default.
- W1454650431 title "Omega‐3 Polyunsaturated Fatty Acid Epoxide Metabolites Are Potent Vasodilators via Potassium Channel Activation" @default.
- W1454650431 doi "https://doi.org/10.1096/fasebj.29.1_supplement.943.7" @default.
- W1454650431 hasPublicationYear "2015" @default.
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