Matches in SemOpenAlex for { <https://semopenalex.org/work/W145465772> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W145465772 endingPage "80" @default.
- W145465772 startingPage "75" @default.
- W145465772 abstract "Jsb is a high-frequency antigen. Anti-Jsb is a rare alloantibody, and its clinical significance is poorly documented. We report a case in which a 12-year-old boy of Nigerian descent with sickle beta- thalassemia presented with multiple alloantibodies, including a panagglutinin and acute chest syndrome, necessitating the emergent transfusion of five units of phenotype-similar, crossmatchincompatible RBCs, four of which were given during an exchange transfusion. The patient was later found to have anti-Jsb. In addition to routine serologic methods to study the patient's RBCs and plasma, a monocyte monolayer assay (MMA) was performed on the patient's samples obtained 2 and 9 days after transfusion of the Js(b+) RBCs to determine the potential clinical significance of the anti-Jsb. Various laboratory parameters including quantitative hemoglobin fraction analyses were used to monitor for increased RBC destruction. The MMA reactivity of the patient's anti-Jsb increased from 2.3 percent on day 2 after transfusion to strongly positive at 88 percent and 66.5 percent (with and without the addition of fresh serum) 1 week later. MMA reactivity of greater than 5 percent is associated with increased RBC destruction. There was no clinical or laboratory evidence of increased hemolysis above baseline. However, decreased RBC survival was suggested by the relatively brisk decrease of the HbA1 fraction after the transfusions. The current case and others reported in the literature suggest that anti-Jsb may have limited potential for causing overt hemolysis. However, in patients with underlying hematologic disease, even mildly increased RBC destruction may pose problems clinically,and thus transfusion of Js(b+) RBCs should be avoided. In emergent situations, the potential of adverse effects of transfusing incompatible units should be balanced against the risk of withholding transfusion. Family members, especially siblings, should be considered as potential designated donors for patients with antibodies directed against high-frequency antigens. Available reports on anti-Jsb in the literature are also reviewed." @default.
- W145465772 created "2016-06-24" @default.
- W145465772 creator A5002422707 @default.
- W145465772 creator A5011912405 @default.
- W145465772 creator A5017525793 @default.
- W145465772 creator A5022644233 @default.
- W145465772 creator A5023007790 @default.
- W145465772 date "2007-01-01" @default.
- W145465772 modified "2023-09-27" @default.
- W145465772 title "Transfusion of multiple units of Js(b+) red blood cells in the presence of anti-Jsb in a patient with sickle beta-thalassemia disease and a review of the literature." @default.
- W145465772 cites W1536111490 @default.
- W145465772 cites W1751195960 @default.
- W145465772 cites W1972416627 @default.
- W145465772 cites W2025316852 @default.
- W145465772 cites W2030675605 @default.
- W145465772 cites W2107917104 @default.
- W145465772 cites W2117466494 @default.
- W145465772 cites W2575733923 @default.
- W145465772 cites W4232429642 @default.
- W145465772 cites W983551924 @default.
- W145465772 cites W2006743295 @default.
- W145465772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18004938" @default.
- W145465772 hasPublicationYear "2007" @default.
- W145465772 type Work @default.
- W145465772 sameAs 145465772 @default.
- W145465772 citedByCount "2" @default.
- W145465772 countsByYear W1454657722012 @default.
- W145465772 countsByYear W1454657722020 @default.
- W145465772 crossrefType "journal-article" @default.
- W145465772 hasAuthorship W145465772A5002422707 @default.
- W145465772 hasAuthorship W145465772A5011912405 @default.
- W145465772 hasAuthorship W145465772A5017525793 @default.
- W145465772 hasAuthorship W145465772A5022644233 @default.
- W145465772 hasAuthorship W145465772A5023007790 @default.
- W145465772 hasConcept C126322002 @default.
- W145465772 hasConcept C159654299 @default.
- W145465772 hasConcept C203014093 @default.
- W145465772 hasConcept C2777799968 @default.
- W145465772 hasConcept C2777940137 @default.
- W145465772 hasConcept C2778917026 @default.
- W145465772 hasConcept C2779042277 @default.
- W145465772 hasConcept C2779134260 @default.
- W145465772 hasConcept C2779902561 @default.
- W145465772 hasConcept C2780014101 @default.
- W145465772 hasConcept C45189115 @default.
- W145465772 hasConcept C63363279 @default.
- W145465772 hasConcept C71924100 @default.
- W145465772 hasConcept C90924648 @default.
- W145465772 hasConceptScore W145465772C126322002 @default.
- W145465772 hasConceptScore W145465772C159654299 @default.
- W145465772 hasConceptScore W145465772C203014093 @default.
- W145465772 hasConceptScore W145465772C2777799968 @default.
- W145465772 hasConceptScore W145465772C2777940137 @default.
- W145465772 hasConceptScore W145465772C2778917026 @default.
- W145465772 hasConceptScore W145465772C2779042277 @default.
- W145465772 hasConceptScore W145465772C2779134260 @default.
- W145465772 hasConceptScore W145465772C2779902561 @default.
- W145465772 hasConceptScore W145465772C2780014101 @default.
- W145465772 hasConceptScore W145465772C45189115 @default.
- W145465772 hasConceptScore W145465772C63363279 @default.
- W145465772 hasConceptScore W145465772C71924100 @default.
- W145465772 hasConceptScore W145465772C90924648 @default.
- W145465772 hasIssue "2" @default.
- W145465772 hasLocation W1454657721 @default.
- W145465772 hasOpenAccess W145465772 @default.
- W145465772 hasPrimaryLocation W1454657721 @default.
- W145465772 hasRelatedWork W195423961 @default.
- W145465772 hasRelatedWork W2017690400 @default.
- W145465772 hasRelatedWork W2051502198 @default.
- W145465772 hasRelatedWork W2164482603 @default.
- W145465772 hasRelatedWork W2383315910 @default.
- W145465772 hasRelatedWork W2403162666 @default.
- W145465772 hasRelatedWork W2572008309 @default.
- W145465772 hasRelatedWork W2891562328 @default.
- W145465772 hasRelatedWork W2990823117 @default.
- W145465772 hasRelatedWork W3210440294 @default.
- W145465772 hasVolume "23" @default.
- W145465772 isParatext "false" @default.
- W145465772 isRetracted "false" @default.
- W145465772 magId "145465772" @default.
- W145465772 workType "article" @default.