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- W145583534 abstract "Publisher Summary The centrosome is the ensemble of structures that nucleates the interphase array of cytoplasmic microtubles and assembles the poles of the mitotic spindle. This chapter discusses the events and controls for centrosome reproduction. Coordination of centrosome reproduction with nuclear events in the cell cycle is also discussed. The sequence of the events of centrosome reproduction is (1) splitting, (2) disorientation, (3) duplication, (4) licensing, (5) disjunction, and (6) separation. The controls for centrosome reproduction are carried by limits that are intrinsic to the centrosome or by extrinsic controls imposed by changing cytoplasmic conditions. The cycle of centrosome reproduction can occur repeatedly in the absence of cell-cycle progression. One way of investigating the coordination of centrosome reproduction and nuclear events in the cell cycle is to characterize which cell-cycle stages support centrosome reproduction and which do not. The approach used is to arrest cells in a particular phase of the cell cycle and then determine if the centrosome reproduces one or more times without further experimental intervention. The sequential activation and inactivation of one or more of the cyclin-dependent kinases (Cdks) could function as the cytoplasmic mechanism that coordinately drives centrosome duplication and nuclear events in the cell cycle." @default.
- W145583534 created "2016-06-24" @default.
- W145583534 creator A5050530888 @default.
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- W145583534 date "1999-01-01" @default.
- W145583534 modified "2023-09-25" @default.
- W145583534 title "The coordination of centrosome reproduction with nuclear events during the cell cycle" @default.
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- W145583534 doi "https://doi.org/10.1016/s0070-2153(99)49013-1" @default.
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