Matches in SemOpenAlex for { <https://semopenalex.org/work/W145591868> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W145591868 abstract "This thesis presents results obtained during a research project aimed at realizing electrochemical single-molecule detection in water. By virtue of being inherently electrical in nature, electrochemical sensors are particularly well suited for integration with microelectronics compared to sensors based on other detection principles. They may thus enable cost effective, massively parallel analysis and diagnostics platforms. However, limited sensitivity and selectivity have been bottlenecks for years in the development of a wide range of bio-electrochemical sensors. In this project, a microfabricated nanogap device with significantly enhanced properties based on redox cycling is developed. With the ability to resolve single molecules, sensitivity is pushed to its most fundamental limit and selectivity can potentially be improved by distinguishing species via their single-molecule signatures.The nanogaps are fabricated with optical lithography and standard microfabrication techniques, they consist of two electrodes with a length in the range of 10 to 100 µm and a width of several microns embedded in the ceiling and floor of a nanofluidic channel with a height of ~50 nm. Redox molecules enter the detection region defined by the two electrodes through entrance holes located at the two ends of the channel. With the electrodes biased at high over-potentials, the molecules are oxidized and reduced repeatedly, generating an amplified current. Preliminary work to characterize and understand the behavior of the device, including how redox couples with different diffusion coefficients and reversible adsorption of analyte species influence its performance, are presented in Chapter 3-5. Based on a self-aligned fabrication scheme that minimizes the gap size and dead volume of the device, redox-cycling efficiency was further improved and electrochemical detection in aqueous solution with single-molecule resolution was achieved. This is the first reported electrochemical detection of single-molecules in water solution in a nanofluidic device. Further building on this approach, we also demonstrated the first study ever to characterize mass transport of individual redox molecules using an electrochemical method. Analysis of the distribution of first-passage times of single molecules suggests anomalous surface diffusion of adsorbed analyte molecules at ultra-low (10 pM) concentrations compared to measurements at high (µM to mM) concentrations." @default.
- W145591868 created "2016-06-24" @default.
- W145591868 creator A5008029640 @default.
- W145591868 date "2014-02-10" @default.
- W145591868 modified "2023-09-23" @default.
- W145591868 title "Single-molecule detection in electrochemical nanogap devices" @default.
- W145591868 doi "https://doi.org/10.3990/1.9789036536363" @default.
- W145591868 hasPublicationYear "2014" @default.
- W145591868 type Work @default.
- W145591868 sameAs 145591868 @default.
- W145591868 citedByCount "0" @default.
- W145591868 crossrefType "dissertation" @default.
- W145591868 hasAuthorship W145591868A5008029640 @default.
- W145591868 hasBestOaLocation W1455918681 @default.
- W145591868 hasConcept C10390740 @default.
- W145591868 hasConcept C120398109 @default.
- W145591868 hasConcept C136525101 @default.
- W145591868 hasConcept C142724271 @default.
- W145591868 hasConcept C147789679 @default.
- W145591868 hasConcept C171250308 @default.
- W145591868 hasConcept C17525397 @default.
- W145591868 hasConcept C185592680 @default.
- W145591868 hasConcept C187937830 @default.
- W145591868 hasConcept C192562407 @default.
- W145591868 hasConcept C204787440 @default.
- W145591868 hasConcept C2778956022 @default.
- W145591868 hasConcept C49040817 @default.
- W145591868 hasConcept C527607 @default.
- W145591868 hasConcept C71924100 @default.
- W145591868 hasConceptScore W145591868C10390740 @default.
- W145591868 hasConceptScore W145591868C120398109 @default.
- W145591868 hasConceptScore W145591868C136525101 @default.
- W145591868 hasConceptScore W145591868C142724271 @default.
- W145591868 hasConceptScore W145591868C147789679 @default.
- W145591868 hasConceptScore W145591868C171250308 @default.
- W145591868 hasConceptScore W145591868C17525397 @default.
- W145591868 hasConceptScore W145591868C185592680 @default.
- W145591868 hasConceptScore W145591868C187937830 @default.
- W145591868 hasConceptScore W145591868C192562407 @default.
- W145591868 hasConceptScore W145591868C204787440 @default.
- W145591868 hasConceptScore W145591868C2778956022 @default.
- W145591868 hasConceptScore W145591868C49040817 @default.
- W145591868 hasConceptScore W145591868C527607 @default.
- W145591868 hasConceptScore W145591868C71924100 @default.
- W145591868 hasLocation W1455918681 @default.
- W145591868 hasOpenAccess W145591868 @default.
- W145591868 hasPrimaryLocation W1455918681 @default.
- W145591868 hasRelatedWork W1547881223 @default.
- W145591868 hasRelatedWork W1998657870 @default.
- W145591868 hasRelatedWork W2040370629 @default.
- W145591868 hasRelatedWork W2041957800 @default.
- W145591868 hasRelatedWork W2050786147 @default.
- W145591868 hasRelatedWork W2063409965 @default.
- W145591868 hasRelatedWork W2110903094 @default.
- W145591868 hasRelatedWork W2153585707 @default.
- W145591868 hasRelatedWork W2285046093 @default.
- W145591868 hasRelatedWork W2545857179 @default.
- W145591868 hasRelatedWork W2610795384 @default.
- W145591868 hasRelatedWork W2739896323 @default.
- W145591868 hasRelatedWork W2759660933 @default.
- W145591868 hasRelatedWork W2765738622 @default.
- W145591868 hasRelatedWork W2904528804 @default.
- W145591868 hasRelatedWork W3004127682 @default.
- W145591868 hasRelatedWork W3016807995 @default.
- W145591868 hasRelatedWork W3136133133 @default.
- W145591868 hasRelatedWork W3176318075 @default.
- W145591868 hasRelatedWork W2187376094 @default.
- W145591868 isParatext "false" @default.
- W145591868 isRetracted "false" @default.
- W145591868 magId "145591868" @default.
- W145591868 workType "dissertation" @default.