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- W1456026887 endingPage "448" @default.
- W1456026887 startingPage "433" @default.
- W1456026887 abstract "This chapter focuses on the immunoglobulin (Ig) genes and development of the antibody repertoire in species that generate their primary antibody repertoires through the extensive somatic diversification of V(D)J heavy and light chain genes. In contrast, the V hand V L of mouse and human, use combinatorial joining of multiple V, (D), and J gene segments to generate the primary repertoire, comprise multiple V hand V L groups. It is possible that species in which the germline genes belong to are only a single group, and therefore have a less diverse repertoire of V gene segments have evolved to utilize somatic hypermutation, gene conversion, or both for developing a highly diversified primary antibody repertoire. Further, the species with less diverse V-gene segments utilize gut-associated lymphoid tissue (GALT) as the site for B-cell expansion and generation of the primary antibody repertoire. It is likely that the somatic diversification in GALT that leads to the primary antibody repertoire is not antigen driven, but instead occurs as a polyclonal response either to an exogenous agent, as occurred in rabbits, or possibly to an endogenous agent, such as a retroviral superantigen in species such as chicken, in which exogenous molecules are not required. Further studies are needed to elucidate the mechanism by which both GALT development and the somatic diversification of the Ig genes are initiated." @default.
- W1456026887 created "2016-06-24" @default.
- W1456026887 creator A5029675961 @default.
- W1456026887 creator A5054663414 @default.
- W1456026887 creator A5056296095 @default.
- W1456026887 date "2004-01-01" @default.
- W1456026887 modified "2023-09-29" @default.
- W1456026887 title "Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT" @default.
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