Matches in SemOpenAlex for { <https://semopenalex.org/work/W145607434> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W145607434 endingPage "501" @default.
- W145607434 startingPage "496" @default.
- W145607434 abstract "Serial measurements of complement components were performed in fifty-nine patients with acute, uncomplicated hepatitis and twelve with alcoholic cirrhosis. Thirty-one of the former group had detectable hepatitis B antigen. Abnormal complement profiles were observed in nine patients with hepatitis B and seven with antigen-negative hepatitis. Low levels of C4, C3 and factor B were common in the subjects with cirrhosis and confined to those cases with severe reduction in serum albumin and/or prothrombin index. By contrast, the complement changes in the patients with hepatitis occurred without significant alteration in these parameters; certain subjects also had reduction in C1q and C5 and a significant number had C3d detectable in fresh plasma. The pattern of abnormality suggests predominant involvement of the classical pathway and it is concluded that this results, at least in part, from an immune process evident only in the early clinical phase of hepatitis. Such gross changes in complement are likely to reflect immune-complex activity and it is proposed that these complexes may be important in the clearance of virus material. The data supports a previous suggestion that recovery from acute hepatitis is primarily dependent on host immune competence rather than viral cytotoxicity or generation of immune complexes." @default.
- W145607434 created "2016-06-24" @default.
- W145607434 creator A5002974398 @default.
- W145607434 creator A5006519779 @default.
- W145607434 creator A5016034637 @default.
- W145607434 creator A5028786576 @default.
- W145607434 creator A5082418112 @default.
- W145607434 date "1977-06-01" @default.
- W145607434 modified "2023-10-18" @default.
- W145607434 title "Acute hepatitis: significance of changes in complement components." @default.
- W145607434 cites W102400508 @default.
- W145607434 cites W1207708767 @default.
- W145607434 cites W146456979 @default.
- W145607434 cites W1965687489 @default.
- W145607434 cites W1967544631 @default.
- W145607434 cites W1979028308 @default.
- W145607434 cites W1984683519 @default.
- W145607434 cites W2002194399 @default.
- W145607434 cites W2002983094 @default.
- W145607434 cites W2018534282 @default.
- W145607434 cites W2032566319 @default.
- W145607434 cites W2044512809 @default.
- W145607434 cites W2047222590 @default.
- W145607434 cites W2052422557 @default.
- W145607434 cites W2066306421 @default.
- W145607434 cites W2080277168 @default.
- W145607434 cites W2143286148 @default.
- W145607434 cites W2314443239 @default.
- W145607434 cites W2395312780 @default.
- W145607434 cites W2414119182 @default.
- W145607434 cites W3112493 @default.
- W145607434 cites W35148275 @default.
- W145607434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1541000" @default.
- W145607434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/891025" @default.
- W145607434 hasPublicationYear "1977" @default.
- W145607434 type Work @default.
- W145607434 sameAs 145607434 @default.
- W145607434 citedByCount "9" @default.
- W145607434 countsByYear W1456074342014 @default.
- W145607434 crossrefType "journal-article" @default.
- W145607434 hasAuthorship W145607434A5002974398 @default.
- W145607434 hasAuthorship W145607434A5006519779 @default.
- W145607434 hasAuthorship W145607434A5016034637 @default.
- W145607434 hasAuthorship W145607434A5028786576 @default.
- W145607434 hasAuthorship W145607434A5082418112 @default.
- W145607434 hasConcept C126322002 @default.
- W145607434 hasConcept C203014093 @default.
- W145607434 hasConcept C2775876817 @default.
- W145607434 hasConcept C2776029263 @default.
- W145607434 hasConcept C2777214474 @default.
- W145607434 hasConcept C2777382497 @default.
- W145607434 hasConcept C71924100 @default.
- W145607434 hasConcept C8891405 @default.
- W145607434 hasConceptScore W145607434C126322002 @default.
- W145607434 hasConceptScore W145607434C203014093 @default.
- W145607434 hasConceptScore W145607434C2775876817 @default.
- W145607434 hasConceptScore W145607434C2776029263 @default.
- W145607434 hasConceptScore W145607434C2777214474 @default.
- W145607434 hasConceptScore W145607434C2777382497 @default.
- W145607434 hasConceptScore W145607434C71924100 @default.
- W145607434 hasConceptScore W145607434C8891405 @default.
- W145607434 hasIssue "3" @default.
- W145607434 hasLocation W1456074341 @default.
- W145607434 hasOpenAccess W145607434 @default.
- W145607434 hasPrimaryLocation W1456074341 @default.
- W145607434 hasRelatedWork W2006257498 @default.
- W145607434 hasRelatedWork W2074112159 @default.
- W145607434 hasRelatedWork W2076423940 @default.
- W145607434 hasRelatedWork W2105573940 @default.
- W145607434 hasRelatedWork W2119997031 @default.
- W145607434 hasRelatedWork W2357298377 @default.
- W145607434 hasRelatedWork W2367164280 @default.
- W145607434 hasRelatedWork W2373519766 @default.
- W145607434 hasRelatedWork W2384074278 @default.
- W145607434 hasRelatedWork W2416512289 @default.
- W145607434 hasVolume "28" @default.
- W145607434 isParatext "false" @default.
- W145607434 isRetracted "false" @default.
- W145607434 magId "145607434" @default.
- W145607434 workType "article" @default.