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- W145629001 abstract "Viral pneumo-enteritis of calves (CPE) is widely distributed in Russia and other foreign countries. The viruses like PIV-3, IBR, BVD, calicivirus, reovirus and adenovirus are considered the main pathogens for CPE, which accounts for 33,2 to 60% in large livestock farms. The colostrum, monoand polyvalent serum are considered the most effective for protection of newborn calves against infections, many of which are developed but not commercially produced. This article presents information on the selection and certification of cell cultures and virus strains of CPE with expressed antigenic properties. Determined the parameters for virus cultivation and manufacture of complex antigens, established the requirements for donors and developed a rational scheme of 4-fold hyperimmunization and exploitation of oxen-producers in mass production of the polyvalent serum against viral CPE. It is proved that the level of accumulation of antibodies in donor blood serum (BS) depends on the activity of viral antigens. Antibody titers in the donors BS immunized with antigens produced in continuous cell lines with roller method was almost 2 times higher than when using primary cell cultures. Proved possibility of equivalent application of cultural antigens and commercial vaccines as antigens. Results achieved by preliminary 2-fold grounding of donors with vaccines against viral CPE, during quarantine, as well as putting into practice «QC System», GMP rules and statistical methods of control on parameters at all stages of production of therapeutic serum. Application of the commercial vaccines as antigens allow receiving the BS with antibody titers that are much lower than when using polyvalent antigens. The preparation is harmless, active and demanded in practice. Preservation of newborn calves undergoing therapy and prophylaxis of viral pneumo-enteritis respectively, 92,8 to 96,7 and 93 to 100 %. Novelty and originality of a method for producing polyvalent BS against viral CPE protected by patent number 2,407,543." @default.
- W145629001 created "2016-06-24" @default.
- W145629001 creator A5062254680 @default.
- W145629001 creator A5084683928 @default.
- W145629001 date "2013-01-01" @default.
- W145629001 modified "2023-09-27" @default.
- W145629001 title "Разработка технологии производства и обеспечения качества поливалентной сыворотки против вирусных пневмоэнтеритов телят" @default.
- W145629001 hasPublicationYear "2013" @default.
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