Matches in SemOpenAlex for { <https://semopenalex.org/work/W1456587059> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1456587059 abstract "Publisher Summary This chapter summarizes several studies to determine whether the Ca 2+ -ATPase is a suitable model for studies of the mechanism of action of volatile anesthetics on plasma membrane proteins. The aim in these studies has been to determine whether the function of the Ca 2+ pump in the plasma membrane is indeed altered by anesthetics. It is demonstrated that the function of red cell Ca 2+ -ATPase is altered by volatile anesthetics. The observed inhibition of enzyme activity occurs at clinically relevant concentrations of the studied volatile anesthetics. Furthermore, the inhibition is dose dependent and reversible. Thus the enzyme meets the crucial criteria for a target for anesthetic action. Several proteins have been reported to be altered by anesthetics in a way suggesting that they could be targets. Some proteins are inhibited by certain agents but not by others, indicating that general anesthetics selectively affect certain proteins. The chapter provides an example supporting the specificity of the anesthetic action on the plasma membrane Ca 2+ -ATPase by showing that the Ca 2+ -independent Mg 2+ -ATPase present in the same red cell membrane is not inhibited by the anesthetics at clinical concentrations. The Ca 2+ -ATPase is inhibited by all four volatile anesthetics as well as by alcohols. A suitable model of an integral membrane protein on which different aspects of anesthetic action can be investigated has been established. An additional advantage of the model is the fact that the enzyme is activated by several modes that are quite frequent in biological systems. These include activation by calmodulin binding, by self-association of enzyme molecules, as well as activation by lipids, proteolysis, and kinase-dependent phosphorylation." @default.
- W1456587059 created "2016-06-24" @default.
- W1456587059 creator A5080502828 @default.
- W1456587059 date "1994-01-01" @default.
- W1456587059 modified "2023-10-16" @default.
- W1456587059 title "Plasma Membrane Ca2+ -ATPase as a Target for Volatile Anesthetics" @default.
- W1456587059 cites W1506884783 @default.
- W1456587059 cites W1536807303 @default.
- W1456587059 cites W1553039892 @default.
- W1456587059 cites W184823884 @default.
- W1456587059 cites W1972647870 @default.
- W1456587059 cites W1974197041 @default.
- W1456587059 cites W1978479842 @default.
- W1456587059 cites W1990257793 @default.
- W1456587059 cites W2000961072 @default.
- W1456587059 cites W2017079235 @default.
- W1456587059 cites W2017151739 @default.
- W1456587059 cites W2018789864 @default.
- W1456587059 cites W2049527501 @default.
- W1456587059 cites W2063183961 @default.
- W1456587059 cites W2086105359 @default.
- W1456587059 cites W2089353585 @default.
- W1456587059 cites W2090100880 @default.
- W1456587059 cites W2135964386 @default.
- W1456587059 cites W72541386 @default.
- W1456587059 doi "https://doi.org/10.1016/s1054-3589(08)60624-9" @default.
- W1456587059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7873420" @default.
- W1456587059 hasPublicationYear "1994" @default.
- W1456587059 type Work @default.
- W1456587059 sameAs 1456587059 @default.
- W1456587059 citedByCount "4" @default.
- W1456587059 crossrefType "book-chapter" @default.
- W1456587059 hasAuthorship W1456587059A5080502828 @default.
- W1456587059 hasConcept C12554922 @default.
- W1456587059 hasConcept C144647389 @default.
- W1456587059 hasConcept C181199279 @default.
- W1456587059 hasConcept C185592680 @default.
- W1456587059 hasConcept C202751555 @default.
- W1456587059 hasConcept C23265538 @default.
- W1456587059 hasConcept C2776120743 @default.
- W1456587059 hasConcept C2778106830 @default.
- W1456587059 hasConcept C2778162923 @default.
- W1456587059 hasConcept C2910438640 @default.
- W1456587059 hasConcept C2994138156 @default.
- W1456587059 hasConcept C41625074 @default.
- W1456587059 hasConcept C42219234 @default.
- W1456587059 hasConcept C55493867 @default.
- W1456587059 hasConcept C71924100 @default.
- W1456587059 hasConcept C86803240 @default.
- W1456587059 hasConceptScore W1456587059C12554922 @default.
- W1456587059 hasConceptScore W1456587059C144647389 @default.
- W1456587059 hasConceptScore W1456587059C181199279 @default.
- W1456587059 hasConceptScore W1456587059C185592680 @default.
- W1456587059 hasConceptScore W1456587059C202751555 @default.
- W1456587059 hasConceptScore W1456587059C23265538 @default.
- W1456587059 hasConceptScore W1456587059C2776120743 @default.
- W1456587059 hasConceptScore W1456587059C2778106830 @default.
- W1456587059 hasConceptScore W1456587059C2778162923 @default.
- W1456587059 hasConceptScore W1456587059C2910438640 @default.
- W1456587059 hasConceptScore W1456587059C2994138156 @default.
- W1456587059 hasConceptScore W1456587059C41625074 @default.
- W1456587059 hasConceptScore W1456587059C42219234 @default.
- W1456587059 hasConceptScore W1456587059C55493867 @default.
- W1456587059 hasConceptScore W1456587059C71924100 @default.
- W1456587059 hasConceptScore W1456587059C86803240 @default.
- W1456587059 hasLocation W14565870591 @default.
- W1456587059 hasLocation W14565870592 @default.
- W1456587059 hasOpenAccess W1456587059 @default.
- W1456587059 hasPrimaryLocation W14565870591 @default.
- W1456587059 hasRelatedWork W1520273710 @default.
- W1456587059 hasRelatedWork W1987874762 @default.
- W1456587059 hasRelatedWork W2004545843 @default.
- W1456587059 hasRelatedWork W2065690850 @default.
- W1456587059 hasRelatedWork W2168825163 @default.
- W1456587059 hasRelatedWork W2357383501 @default.
- W1456587059 hasRelatedWork W2415805830 @default.
- W1456587059 hasRelatedWork W2899084033 @default.
- W1456587059 hasRelatedWork W3110055093 @default.
- W1456587059 hasRelatedWork W4290315474 @default.
- W1456587059 isParatext "false" @default.
- W1456587059 isRetracted "false" @default.
- W1456587059 magId "1456587059" @default.
- W1456587059 workType "book-chapter" @default.