Matches in SemOpenAlex for { <https://semopenalex.org/work/W1458161714> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1458161714 abstract "Felbamate (FBM) use in treatment of pediatric and adult epilepsy has sharply declined since early reports of FBM- associated hematologic and hepatic injury. We retrospectively reviewed the efficacy and safety profile of FBM in children and young adults with intractable epilepsy treated with this antiepileptic drug as adjunctive therapy in our pediatric epilepsy clinic from 2001-2010. We identified 101 patients 2-22 yr (mean 12.8 ± 1.8 yr) with various seizure types and epilepsy syn- dromes. FBM dosing was titrated according to tolerability and seizure control. Mean duration of FBM treatment was 43.7 ± 30.4 mo. Patients had periodic serum drug levels, serum hematologic and metabolic panels and body-mass index measurements during treatment and follow-up. No patient had serious adverse effects, including aplastic anemia or hepatic failure. Using sub- jective seizure counts, FBM also seemed to be effective in seizure control; 22 (22%) patients were reported as seizure-free; 59 (59%) patients were said by parents to have had fewer seizures, and 20 (20%) patients were estimated as having unchanged sei- zure frequency. Weight loss, though typically mild, was the major adverse effect. In children older than 3 yr, 46 (53%) of 86 lost weight during FBM administration and 40 (47%) children gained weight. No patients required discontinuation of FBM due to adverse effects. FBM was well-tolerated and without serious adverse effects in our patients. FBM seemed to be effective in reducing seizure frequency. It should be considered a viable current option for treatment of intractable seizures in children, though weight should be monitored in these patients." @default.
- W1458161714 created "2016-06-24" @default.
- W1458161714 creator A5010385927 @default.
- W1458161714 creator A5015536891 @default.
- W1458161714 creator A5027810115 @default.
- W1458161714 creator A5070962198 @default.
- W1458161714 creator A5075320882 @default.
- W1458161714 date "2015-07-18" @default.
- W1458161714 modified "2023-09-23" @default.
- W1458161714 title "Felbamate in intractable pediatric and young adult epilepsy" @default.
- W1458161714 cites W1434269350 @default.
- W1458161714 cites W1972525157 @default.
- W1458161714 cites W1992469827 @default.
- W1458161714 cites W2000265757 @default.
- W1458161714 cites W2003806812 @default.
- W1458161714 cites W2015342345 @default.
- W1458161714 cites W2016909246 @default.
- W1458161714 cites W2037943114 @default.
- W1458161714 cites W2055381303 @default.
- W1458161714 cites W2058033216 @default.
- W1458161714 cites W2080557063 @default.
- W1458161714 cites W2115275904 @default.
- W1458161714 cites W2124279185 @default.
- W1458161714 cites W2129641957 @default.
- W1458161714 cites W2130786729 @default.
- W1458161714 cites W2141344427 @default.
- W1458161714 cites W2143258645 @default.
- W1458161714 cites W2415389564 @default.
- W1458161714 doi "https://doi.org/10.3233/pep-13052" @default.
- W1458161714 hasPublicationYear "2015" @default.
- W1458161714 type Work @default.
- W1458161714 sameAs 1458161714 @default.
- W1458161714 citedByCount "0" @default.
- W1458161714 crossrefType "journal-article" @default.
- W1458161714 hasAuthorship W1458161714A5010385927 @default.
- W1458161714 hasAuthorship W1458161714A5015536891 @default.
- W1458161714 hasAuthorship W1458161714A5027810115 @default.
- W1458161714 hasAuthorship W1458161714A5070962198 @default.
- W1458161714 hasAuthorship W1458161714A5075320882 @default.
- W1458161714 hasConcept C118552586 @default.
- W1458161714 hasConcept C126322002 @default.
- W1458161714 hasConcept C187212893 @default.
- W1458161714 hasConcept C197934379 @default.
- W1458161714 hasConcept C2775858608 @default.
- W1458161714 hasConcept C2778186239 @default.
- W1458161714 hasConcept C2778375690 @default.
- W1458161714 hasConcept C2778715236 @default.
- W1458161714 hasConcept C2780874087 @default.
- W1458161714 hasConcept C2781011581 @default.
- W1458161714 hasConcept C3018325526 @default.
- W1458161714 hasConcept C42219234 @default.
- W1458161714 hasConcept C71924100 @default.
- W1458161714 hasConceptScore W1458161714C118552586 @default.
- W1458161714 hasConceptScore W1458161714C126322002 @default.
- W1458161714 hasConceptScore W1458161714C187212893 @default.
- W1458161714 hasConceptScore W1458161714C197934379 @default.
- W1458161714 hasConceptScore W1458161714C2775858608 @default.
- W1458161714 hasConceptScore W1458161714C2778186239 @default.
- W1458161714 hasConceptScore W1458161714C2778375690 @default.
- W1458161714 hasConceptScore W1458161714C2778715236 @default.
- W1458161714 hasConceptScore W1458161714C2780874087 @default.
- W1458161714 hasConceptScore W1458161714C2781011581 @default.
- W1458161714 hasConceptScore W1458161714C3018325526 @default.
- W1458161714 hasConceptScore W1458161714C42219234 @default.
- W1458161714 hasConceptScore W1458161714C71924100 @default.
- W1458161714 hasLocation W14581617141 @default.
- W1458161714 hasOpenAccess W1458161714 @default.
- W1458161714 hasPrimaryLocation W14581617141 @default.
- W1458161714 isParatext "false" @default.
- W1458161714 isRetracted "false" @default.
- W1458161714 magId "1458161714" @default.
- W1458161714 workType "article" @default.