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- W145878840 abstract "Studies have shown that the CBA/J strain of mice is more susceptible than the C57BL/6J strain to the fetotoxic effects of ethanol (E), and that this difference is related to the maternal metabolism of E. Since B shares many of the pharmacological actions of E but is not metabolized by the same mechanisms, this study was performed to compare the prenatal effects of B between these strains of mice. Pregnant mice of each strain were given either B (1 ml/kg, p.o.; 10% in tap water) or an equivalent volume of tap water twice daily on day 6 through 18 of gestation (day 0 = vaginal plug). The animals were sacrificed on day 18 and the fetuses prepared for either soft tissue or skeletal examination. There were significantly more resorptions per litter in the B-treated animals (46% vs. 13% control), but no difference between strains was observed. B did not affect the body weight of the survivors nor produce significant anomalies in either strain. The absence of an interstrain difference in resorptions supports the conclusion that the difference in the lethal effects of E is related to maternal metabolism of E. The failure of B to produce structural anomalies or reducemore » fetal weight suggests that these are effects which depend on either the metabolism of E, or pharmacodynamic actions of E not shared by B.« less" @default.
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- W145878840 date "1986-03-01" @default.
- W145878840 modified "2023-09-24" @default.
- W145878840 title "Prenatal effects of tertiary butanol (B) in CBA/J and C57BL/6J mice" @default.
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