FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1459075165> ?p ?o ?g. }

• W1459075165 endingPage "287" @default.
• W1459075165 startingPage "278" @default.
• W1459075165 abstract "This chapter discusses the introduction and modification of substituent groups, new methods for ring annelation, and synthetically useful ring transformation reactions; the three areas of heterocyclic chemistry. Numerous new methods for the introduction and modification of substituents continue to appear, reflecting the fact that this area of heterocyclic chemistry contains many of its greatest synthetic challenges. The introduction of substituent groups into protonated heterocyclic bases by free radicals, pioneered by Minisci and well reviewed over the past few years continues to be actively explored; further studies on alkylations, acylations, and carboethoxylations have been reported. Various substituents are readily displaced by an ipso substitution process from the 2-position of benzothiazole by the nucleophilic 1-adamantyl and acetyl radicals. The extension of these substituent group interchange processes to other heterocyclic systems could be of considerable synthetic utility. A general procedure for the introduction of substituents in heterocycles is the displacement of a good leaving group by an appropriate nucleophile. The most reactive substituent toward the displacement by nucleophiles appears to be methylsulfonyl. A versatile procedure for the introduction of alkyl, alkenyl, and epoxyalkyl groups into heterocycles, followed by appropriate manipulation of the resulting ylides, has been applied to the synthesis of various 6-substituted purines designed as inhibitors of adenylsuccinate synthetase and lyase. The chapter also discusses many recent developments in synthetic methodology in heterocyclic chemistry have dealt with new methods for annelation of a heterocyclic ring unto a pre-existing ring system. Many useful syntheses involve the deliberate transformation of one heterocyclic system into another by ring contraction, ring expansion, or ring transformation reaction." @default.
• W1459075165 created "2016-06-24" @default.
• W1459075165 creator A5070242155 @default.
• W1459075165 date "1979-01-01" @default.
• W1459075165 modified "2023-09-27" @default.
• W1459075165 title "Chapter 27 New Methods in Heterocyclic Chemistry" @default.
• W1459075165 cites W1432022817 @default.
• W1459075165 cites W1510559973 @default.
• W1459075165 cites W1588133348 @default.
• W1459075165 cites W164444027 @default.
• W1459075165 cites W1966128618 @default.
• W1459075165 cites W1966837986 @default.
• W1459075165 cites W1967365390 @default.
• W1459075165 cites W1969915346 @default.
• W1459075165 cites W1974323091 @default.
• W1459075165 cites W1975463256 @default.
• W1459075165 cites W1976453385 @default.
• W1459075165 cites W1978290337 @default.
• W1459075165 cites W1984609328 @default.
• W1459075165 cites W1984659682 @default.
• W1459075165 cites W1985995672 @default.
• W1459075165 cites W1987375037 @default.
• W1459075165 cites W1994376509 @default.
• W1459075165 cites W1995370911 @default.
• W1459075165 cites W2009294101 @default.
• W1459075165 cites W2010152446 @default.
• W1459075165 cites W2011428398 @default.
• W1459075165 cites W2030125339 @default.
• W1459075165 cites W2030844073 @default.
• W1459075165 cites W2035259224 @default.
• W1459075165 cites W2039251787 @default.
• W1459075165 cites W2046409124 @default.
• W1459075165 cites W2046823508 @default.
• W1459075165 cites W2047669990 @default.
• W1459075165 cites W2052781469 @default.
• W1459075165 cites W2053939277 @default.
• W1459075165 cites W2057634448 @default.
• W1459075165 cites W2061593246 @default.
• W1459075165 cites W2067226303 @default.
• W1459075165 cites W2068956655 @default.
• W1459075165 cites W2073774637 @default.
• W1459075165 cites W2080400218 @default.
• W1459075165 cites W2080594844 @default.
• W1459075165 cites W2084249330 @default.
• W1459075165 cites W2090780307 @default.
• W1459075165 cites W2093415775 @default.
• W1459075165 cites W2099504853 @default.
• W1459075165 cites W2111926241 @default.
• W1459075165 cites W2122906152 @default.
• W1459075165 cites W2131365748 @default.
• W1459075165 cites W2312791757 @default.
• W1459075165 cites W2322483731 @default.
• W1459075165 cites W2330966111 @default.
• W1459075165 cites W2561175576 @default.
• W1459075165 cites W2949234627 @default.
• W1459075165 cites W2949263603 @default.
• W1459075165 cites W2949348638 @default.
• W1459075165 cites W2950698932 @default.
• W1459075165 cites W2950809787 @default.
• W1459075165 cites W2950861955 @default.
• W1459075165 cites W2951681009 @default.
• W1459075165 cites W94327412 @default.
• W1459075165 cites W2004053318 @default.
• W1459075165 cites W2058115585 @default.
• W1459075165 doi "https://doi.org/10.1016/s0065-7743(08)61372-x" @default.
• W1459075165 hasPublicationYear "1979" @default.
• W1459075165 type Work @default.
• W1459075165 sameAs 1459075165 @default.
• W1459075165 citedByCount "0" @default.
• W1459075165 crossrefType "book-chapter" @default.
• W1459075165 hasAuthorship W1459075165A5070242155 @default.
• W1459075165 hasConcept C145148216 @default.
• W1459075165 hasConcept C161790260 @default.
• W1459075165 hasConcept C178790620 @default.
• W1459075165 hasConcept C178907741 @default.
• W1459075165 hasConcept C185592680 @default.
• W1459075165 hasConcept C21951064 @default.
• W1459075165 hasConcept C2778689049 @default.
• W1459075165 hasConcept C2780378348 @default.
• W1459075165 hasConcept C30095370 @default.
• W1459075165 hasConcept C71240020 @default.
• W1459075165 hasConcept C7512685 @default.
• W1459075165 hasConceptScore W1459075165C145148216 @default.
• W1459075165 hasConceptScore W1459075165C161790260 @default.
• W1459075165 hasConceptScore W1459075165C178790620 @default.
• W1459075165 hasConceptScore W1459075165C178907741 @default.
• W1459075165 hasConceptScore W1459075165C185592680 @default.
• W1459075165 hasConceptScore W1459075165C21951064 @default.
• W1459075165 hasConceptScore W1459075165C2778689049 @default.
• W1459075165 hasConceptScore W1459075165C2780378348 @default.
• W1459075165 hasConceptScore W1459075165C30095370 @default.
• W1459075165 hasConceptScore W1459075165C71240020 @default.
• W1459075165 hasConceptScore W1459075165C7512685 @default.
• W1459075165 hasLocation W14590751651 @default.
• W1459075165 hasOpenAccess W1459075165 @default.
• W1459075165 hasPrimaryLocation W14590751651 @default.
• W1459075165 hasRelatedWork W1523127680 @default.
• W1459075165 hasRelatedWork W1989523269 @default.

• next