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- W1459091947 abstract "Binding of the PRR to renin and prorenin activates intracellular signals independent of angiotensin II. The PRR is a component of the Wnt signaling pathway working as an adaptor between Wnt receptor and the vacuolar H+-ATPase. The expression of PRR is increased in the heart and kidney of hypertensive and diabetic animals; however its role in renal damage remains unclear. In this study we tested the hypothesis that the PRR activation induces the expression of fibronectin and collagen I via the b-catenin pathway in mouse collecting duct M-1 cells. Human recombinant prorenin (hrPR) for 16 h in M-1 cells increased the mRNA and protein levels of fibronectin (1.48±0.1 fold change), collagen I (1.53±0.1 fold-change) as well as the b-catenin target genes, cyclin D1 (1.9 ± 0.1 fold change) and c-myc (2.1 ± 0.2 fold change). Inhibition of b-catenin degradation with pyrvinium pamoate (10-9 M) did not prevent the hrPR-induced expression of all these genes. However, when the cells were transfected with a siRNA-PRR, the hrPR-dependent increases in fibronectin, collagen, cyclin D1 and c-myc were prevented. Furthermore, hrPR treatment did not change the stationary protein level of β-catenin or phosphorylation of GSK-3β until 24h, but the level of pERK1/2 displayed a significant increase after 8h of treatment (2.9 ± 0.21 fold change, P<0.05).These results indicate that in collecting duct cells, PRR activation stimulates fibrotic genes independent of β-catenin pathway." @default.
- W1459091947 created "2016-06-24" @default.
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- W1459091947 date "2015-04-01" @default.
- W1459091947 modified "2023-10-16" @default.
- W1459091947 title "The activation of the(Pro)renin receptor (PRR) stimulates fibrotic factors expression independent of b‐catenin signaling pathway in collecting duct cells" @default.
- W1459091947 doi "https://doi.org/10.1096/fasebj.29.1_supplement.971.5" @default.
- W1459091947 hasPublicationYear "2015" @default.
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