Matches in SemOpenAlex for { <https://semopenalex.org/work/W1459590947> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1459590947 endingPage "69" @default.
- W1459590947 startingPage "259" @default.
- W1459590947 abstract "Connective tissue function is defined as the formation and maintenance of shape, without which centralised physiologies (circulatory, digestive or nervous) could not have evolved. Two elements, inextensible (collagenous) fibrils and compression-resistant interfibrillar soluble polymers (proteoglycans), cope with all usual stresses. Relationships between the two are highly specific, as demonstrated by electron histochemistry based on Cupromeronic blue and critical electrolyte concentration (CEC) methodologies. Recent ideas on (1) the protofibrillar or modular structure of collagen fibrils, (2) the nature of specific binding sites for proteoglycans on fibrils, and (3) fundamental similarities in secondary and tertiary structures of the glycosaminoglycans (hyaluronan, chondroitin, keratan and dermatan sulphates) are described. They have greatly illuminated the study of extracellular matrix structure and function in normal, pathological (osteogenesis imperfecta) and ageing tissues. The small proteoglycans are proposed to be tissue organisers, orienting and ordering the collagen fibrils--thus shaping the tissue at a molecular and ultimately macro level. These interfibrillar structures are based on their bifunctional character, the protein parts binding to collagen fibrils at specific sites and the glycosaminoglycans duplexing and aggregating to hold the proteins and hence the collagen fibrils at defined distances from each other, rather like yardsticks. Examples of the way these functions work in specific tissues are drawn from the cornea and vitreous humour of the eye and developing tendon." @default.
- W1459590947 created "2016-06-24" @default.
- W1459590947 creator A5000933548 @default.
- W1459590947 date "1995-10-01" @default.
- W1459590947 modified "2023-09-23" @default.
- W1459590947 title "Extracellular matrix, supramolecular organisation and shape." @default.
- W1459590947 cites W125147743 @default.
- W1459590947 cites W159502088 @default.
- W1459590947 cites W1787865208 @default.
- W1459590947 cites W196883261 @default.
- W1459590947 cites W2028967986 @default.
- W1459590947 cites W2031321015 @default.
- W1459590947 cites W2052295777 @default.
- W1459590947 cites W2069034480 @default.
- W1459590947 cites W2109099861 @default.
- W1459590947 cites W2139743014 @default.
- W1459590947 cites W2343793344 @default.
- W1459590947 cites W318927918 @default.
- W1459590947 cites W42459597 @default.
- W1459590947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1167422" @default.
- W1459590947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7591990" @default.
- W1459590947 hasPublicationYear "1995" @default.
- W1459590947 type Work @default.
- W1459590947 sameAs 1459590947 @default.
- W1459590947 citedByCount "64" @default.
- W1459590947 countsByYear W14595909472012 @default.
- W1459590947 countsByYear W14595909472013 @default.
- W1459590947 countsByYear W14595909472015 @default.
- W1459590947 countsByYear W14595909472016 @default.
- W1459590947 countsByYear W14595909472017 @default.
- W1459590947 countsByYear W14595909472018 @default.
- W1459590947 countsByYear W14595909472019 @default.
- W1459590947 countsByYear W14595909472021 @default.
- W1459590947 countsByYear W14595909472022 @default.
- W1459590947 countsByYear W14595909472023 @default.
- W1459590947 crossrefType "journal-article" @default.
- W1459590947 hasAuthorship W1459590947A5000933548 @default.
- W1459590947 hasConcept C105702510 @default.
- W1459590947 hasConcept C12554922 @default.
- W1459590947 hasConcept C153074725 @default.
- W1459590947 hasConcept C185592680 @default.
- W1459590947 hasConcept C189165786 @default.
- W1459590947 hasConcept C27523624 @default.
- W1459590947 hasConcept C2776735749 @default.
- W1459590947 hasConcept C2779869378 @default.
- W1459590947 hasConcept C2780105995 @default.
- W1459590947 hasConcept C28406088 @default.
- W1459590947 hasConcept C3019161014 @default.
- W1459590947 hasConcept C518705261 @default.
- W1459590947 hasConcept C54355233 @default.
- W1459590947 hasConcept C55493867 @default.
- W1459590947 hasConcept C86803240 @default.
- W1459590947 hasConcept C95444343 @default.
- W1459590947 hasConceptScore W1459590947C105702510 @default.
- W1459590947 hasConceptScore W1459590947C12554922 @default.
- W1459590947 hasConceptScore W1459590947C153074725 @default.
- W1459590947 hasConceptScore W1459590947C185592680 @default.
- W1459590947 hasConceptScore W1459590947C189165786 @default.
- W1459590947 hasConceptScore W1459590947C27523624 @default.
- W1459590947 hasConceptScore W1459590947C2776735749 @default.
- W1459590947 hasConceptScore W1459590947C2779869378 @default.
- W1459590947 hasConceptScore W1459590947C2780105995 @default.
- W1459590947 hasConceptScore W1459590947C28406088 @default.
- W1459590947 hasConceptScore W1459590947C3019161014 @default.
- W1459590947 hasConceptScore W1459590947C518705261 @default.
- W1459590947 hasConceptScore W1459590947C54355233 @default.
- W1459590947 hasConceptScore W1459590947C55493867 @default.
- W1459590947 hasConceptScore W1459590947C86803240 @default.
- W1459590947 hasConceptScore W1459590947C95444343 @default.
- W1459590947 hasLocation W14595909471 @default.
- W1459590947 hasOpenAccess W1459590947 @default.
- W1459590947 hasPrimaryLocation W14595909471 @default.
- W1459590947 hasRelatedWork W1459590947 @default.
- W1459590947 hasRelatedWork W1484074649 @default.
- W1459590947 hasRelatedWork W1972684310 @default.
- W1459590947 hasRelatedWork W1973003537 @default.
- W1459590947 hasRelatedWork W2016950229 @default.
- W1459590947 hasRelatedWork W2034208587 @default.
- W1459590947 hasRelatedWork W2043371368 @default.
- W1459590947 hasRelatedWork W2083284731 @default.
- W1459590947 hasRelatedWork W2095125771 @default.
- W1459590947 hasRelatedWork W2149496973 @default.
- W1459590947 hasVolume "187 ( Pt 2)" @default.
- W1459590947 isParatext "false" @default.
- W1459590947 isRetracted "false" @default.
- W1459590947 magId "1459590947" @default.
- W1459590947 workType "article" @default.