Matches in SemOpenAlex for { <https://semopenalex.org/work/W1459883720> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1459883720 endingPage "1503" @default.
- W1459883720 startingPage "1503" @default.
- W1459883720 abstract "AACR Annual Meeting-- Apr 18-22, 2009; Denver, COSignal transducer and activator of transcription factor 5 (STAT5) has two isoforms, STAT5A and STAT5B, encoded by two separate genes. They play a pivotal role in the development and differentiation of the mammary gland. Studies with mouse models of breast cancer have suggested that STAT5A/B may promote malignant transformation and enhance growth of the early tumour. Constitutive activation of STAT5 has also been observed in human mammary carcinoma along with various other types of malignancies. Distinctive roles for STAT5A and STAT5B in neoplasia have been implied in recent studies. In the present study, the functions of STAT5A and STAT5B have been systematically delineated in human mammary carcinoma cells. We demonstrated that forced expression of constitutively-active (CA) STAT5, i.e. CA-STAT5A or CA-STAT5B, in MCF-7 mammary carcinoma cell line, minimally affected cell cycle progression and proliferation in monolayer. However, forced expression of either CA-STAT5A or CA-STAT5B in MCF-7 mammary carcinoma cell line significantly decreased apoptosis and enhanced colony formation in soft agar with the effects of CA-STAT5A being greater than CA-STAT5B. In addition, forced expression of CA-STAT5A in MCF-7 cells, but not CA-STAT5B, significantly attenuated colony scattering, migration and invasion via strengthening cell homotypic adhesion. Reciprocally, depletion of endogenous STAT5A by siRNA in MCF-7 cells significantly enhanced colony scattering, migration and invasion, while depletion of endogenous STAT5B by siRNA exhibited little effect. Depletion of STAT5A also very significantly impaired colony formation of MCF-7 cells in soft agar, whereas a smaller reduction was observed upon siRNA-mediated depletion of STAT5B. Therefore, we have demonstrated that STAT5A and STAT5B function differentially in regulating the cellular behaviour of mammary carcinoma cells.Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1503." @default.
- W1459883720 created "2016-06-24" @default.
- W1459883720 creator A5032833319 @default.
- W1459883720 creator A5051119189 @default.
- W1459883720 creator A5056528169 @default.
- W1459883720 date "2009-05-01" @default.
- W1459883720 modified "2023-09-25" @default.
- W1459883720 title "Abstract #1503: The differentiated role of STAT5A and STAT5B in mammary carcinoma cell behavior" @default.
- W1459883720 hasPublicationYear "2009" @default.
- W1459883720 type Work @default.
- W1459883720 sameAs 1459883720 @default.
- W1459883720 citedByCount "0" @default.
- W1459883720 crossrefType "journal-article" @default.
- W1459883720 hasAuthorship W1459883720A5032833319 @default.
- W1459883720 hasAuthorship W1459883720A5051119189 @default.
- W1459883720 hasAuthorship W1459883720A5056528169 @default.
- W1459883720 hasConcept C1491633281 @default.
- W1459883720 hasConcept C2779391668 @default.
- W1459883720 hasConcept C502942594 @default.
- W1459883720 hasConcept C54355233 @default.
- W1459883720 hasConcept C62112901 @default.
- W1459883720 hasConcept C62478195 @default.
- W1459883720 hasConcept C86803240 @default.
- W1459883720 hasConcept C95444343 @default.
- W1459883720 hasConceptScore W1459883720C1491633281 @default.
- W1459883720 hasConceptScore W1459883720C2779391668 @default.
- W1459883720 hasConceptScore W1459883720C502942594 @default.
- W1459883720 hasConceptScore W1459883720C54355233 @default.
- W1459883720 hasConceptScore W1459883720C62112901 @default.
- W1459883720 hasConceptScore W1459883720C62478195 @default.
- W1459883720 hasConceptScore W1459883720C86803240 @default.
- W1459883720 hasConceptScore W1459883720C95444343 @default.
- W1459883720 hasLocation W14598837201 @default.
- W1459883720 hasOpenAccess W1459883720 @default.
- W1459883720 hasPrimaryLocation W14598837201 @default.
- W1459883720 hasRelatedWork W1499637336 @default.
- W1459883720 hasRelatedWork W1984803226 @default.
- W1459883720 hasRelatedWork W1997480385 @default.
- W1459883720 hasRelatedWork W2066693406 @default.
- W1459883720 hasRelatedWork W2110790636 @default.
- W1459883720 hasRelatedWork W2130771246 @default.
- W1459883720 hasRelatedWork W2138012923 @default.
- W1459883720 hasRelatedWork W2143527813 @default.
- W1459883720 hasRelatedWork W2168350623 @default.
- W1459883720 hasRelatedWork W2183678352 @default.
- W1459883720 hasRelatedWork W2330217893 @default.
- W1459883720 hasRelatedWork W2410832741 @default.
- W1459883720 hasRelatedWork W2600527456 @default.
- W1459883720 hasRelatedWork W2776869003 @default.
- W1459883720 hasRelatedWork W2979819261 @default.
- W1459883720 hasRelatedWork W3031957649 @default.
- W1459883720 hasRelatedWork W3092625883 @default.
- W1459883720 hasRelatedWork W3143729006 @default.
- W1459883720 hasRelatedWork W3181787355 @default.
- W1459883720 hasRelatedWork W2950041293 @default.
- W1459883720 hasVolume "69" @default.
- W1459883720 isParatext "false" @default.
- W1459883720 isRetracted "false" @default.
- W1459883720 magId "1459883720" @default.
- W1459883720 workType "article" @default.