Matches in SemOpenAlex for { <https://semopenalex.org/work/W14599648> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W14599648 abstract "Most congenital malformations of which the cause is known are due to genetic or multifactorial causes or are secondary to a teratogen. Many congenital malformations are of unknown origin. However, the association of different malformations allows us to define the moment in which the noxous agent affected embryonic or foetal development.We present the case of a baby born after 40 weeks gestation, who had been exposed to ionising radiation before birth. Prenatal echography showed microcephaly and the karyotype was normal. The newborn baby had corneal opacities, microcephaly and complex encephalic malformations. The corneal opacity together with congenital glaucoma constitute Peters syndrome which leads to blindness, and is treated by trabeculectomy and bilateral corneal transplants. The microcephaly and lobar holoprosencephaly with agenesis of the corpus callosum led to reduced psychomotor development, hypertonia and epilepsy with an electroencephalogram recording of hemihypsarrythmia which was unsuccessfully treated with valproate and vigabatrine. At the age of 21 months the patient developed an embryonic rhabdomyosarcoma of the base of the tongue. He died with systemic infection whilst being treated with chemotherapy.The association of the malformations described has not previously been reported in the international data bases. Although it was not possible to prove that prenatal exposure to radiation caused the clinical condition described, the possibility of teratogenesis and carcinogenesis following such exposure means that pregnant women or those who may be pregnant should not be in places where radiodiagnosis is carried out." @default.
- W14599648 created "2016-06-24" @default.
- W14599648 creator A5021460712 @default.
- W14599648 creator A5068245778 @default.
- W14599648 creator A5091373069 @default.
- W14599648 date "2001-01-01" @default.
- W14599648 modified "2023-09-24" @default.
- W14599648 title "Microcefalia, opacidad corneal bilateral y holoprosencefalia lobar congénitas con desarrollo posterior de un rabdomiosarcoma en un paciente expuesto a radiación prenatal" @default.
- W14599648 doi "https://doi.org/10.33588/rn.3310.2001168" @default.
- W14599648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11785006" @default.
- W14599648 hasPublicationYear "2001" @default.
- W14599648 type Work @default.
- W14599648 sameAs 14599648 @default.
- W14599648 citedByCount "2" @default.
- W14599648 countsByYear W145996482023 @default.
- W14599648 crossrefType "journal-article" @default.
- W14599648 hasAuthorship W14599648A5021460712 @default.
- W14599648 hasAuthorship W14599648A5068245778 @default.
- W14599648 hasAuthorship W14599648A5091373069 @default.
- W14599648 hasConcept C104317684 @default.
- W14599648 hasConcept C105702510 @default.
- W14599648 hasConcept C142724271 @default.
- W14599648 hasConcept C172680121 @default.
- W14599648 hasConcept C187212893 @default.
- W14599648 hasConcept C2776395126 @default.
- W14599648 hasConcept C2777424935 @default.
- W14599648 hasConcept C2778085061 @default.
- W14599648 hasConcept C2778183499 @default.
- W14599648 hasConcept C2778256501 @default.
- W14599648 hasConcept C2779234561 @default.
- W14599648 hasConcept C2780787877 @default.
- W14599648 hasConcept C2780844630 @default.
- W14599648 hasConcept C2781374659 @default.
- W14599648 hasConcept C54355233 @default.
- W14599648 hasConcept C71924100 @default.
- W14599648 hasConcept C86803240 @default.
- W14599648 hasConceptScore W14599648C104317684 @default.
- W14599648 hasConceptScore W14599648C105702510 @default.
- W14599648 hasConceptScore W14599648C142724271 @default.
- W14599648 hasConceptScore W14599648C172680121 @default.
- W14599648 hasConceptScore W14599648C187212893 @default.
- W14599648 hasConceptScore W14599648C2776395126 @default.
- W14599648 hasConceptScore W14599648C2777424935 @default.
- W14599648 hasConceptScore W14599648C2778085061 @default.
- W14599648 hasConceptScore W14599648C2778183499 @default.
- W14599648 hasConceptScore W14599648C2778256501 @default.
- W14599648 hasConceptScore W14599648C2779234561 @default.
- W14599648 hasConceptScore W14599648C2780787877 @default.
- W14599648 hasConceptScore W14599648C2780844630 @default.
- W14599648 hasConceptScore W14599648C2781374659 @default.
- W14599648 hasConceptScore W14599648C54355233 @default.
- W14599648 hasConceptScore W14599648C71924100 @default.
- W14599648 hasConceptScore W14599648C86803240 @default.
- W14599648 hasLocation W145996481 @default.
- W14599648 hasLocation W145996482 @default.
- W14599648 hasOpenAccess W14599648 @default.
- W14599648 hasPrimaryLocation W145996481 @default.
- W14599648 isParatext "false" @default.
- W14599648 isRetracted "false" @default.
- W14599648 magId "14599648" @default.
- W14599648 workType "article" @default.