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- W1461179819 abstract "DER represents the isolated Drosophila melanogaster homologue of the EGF receptor (EGFR) family. The DER protein was shown to have PTK activity. The gene is expressed in a wide array of tissues and was shown by analysis of mutant phenotypes to have multiple roles during development, most notably in the establishment of embryonic cell fates, in the differentiation of cells in the eye imaginal disc and other discs, and in determination of dorsal polarity in the follicle cells surrounding the oocyte. The DER protein is synthesized as a single polypeptide chain. Two isoforms (types I and II) are encoded because of alternative splicing, altering the extreme N-terminal coding sequence. In domain structure, the protein has a signal peptide (contributed by the type I or II5 2 exons), and a single transmembrane domain. The extracellular region contains two cysteine-rich stretches. The cytoplasmic region includes the highly conserved kinase domain, and the C-terminal tail containing tyrosine residues that may serve as sites for autophosphorylation." @default.
- W1461179819 created "2016-06-24" @default.
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- W1461179819 date "1995-01-01" @default.
- W1461179819 modified "2023-09-27" @default.
- W1461179819 title "DER" @default.
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- W1461179819 doi "https://doi.org/10.1016/b978-012324719-3/50167-9" @default.
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