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- W1461283487 abstract "Although the cell type conversion of pigmented epithelial cells (PECs) can be observed in the process of Wolffian lens regeneration and of neural retina regeneration in a limited number of species, the results of cell culture works since 1973 permit to conclude that the population of PECs capable of transdifferentiation is widely conserved in vertebrates including humans, at least in the embryonic period. However, this multipotential property is well stabilized in physiological conditions in situ. The finding that close cell–cell contact may be one of the requisites for the stabilization of PECs is revealed by observations of a cohesive epithelial cell sheet supported by a continuous collagen substrate. This chapter establishes a culture system in which a pure population of dedifferentiated cells (dePECs) can be maintained by introducing phenylthiourea (PTU), hyaluronidase (HUase), and dialyzed fetal bovine serum in an appropriate way. With this system, the cellular properties of dePECs can be investigated in detail. Preliminary efforts to elucidate the mechanisms of transdifferentiation in terms of the regulation of gene expression have been started. It has been demonstrated that δ-crystallin mature mRNA can be detected in some nonlenticular tissues, such as pigment epithelium, neural retina, and others, in early chick embryos in situ. To further understand the multipotent dedifferentiated state of PECs at the level of gene expression, it is necessary to extend investigation to the transcription of genes that are specifically expressed in the melanogenic cell and to determine whether the transcripts are also present in dePECs." @default.
- W1461283487 created "2016-06-24" @default.
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- W1461283487 date "1986-01-01" @default.
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- W1461283487 title "Chapter 2 Instability in Cell Commitment of Vertebrate Pigmented Epithelial Cells and their Transdifferentiation into Lens Cells" @default.
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- W1461283487 doi "https://doi.org/10.1016/s0070-2153(08)60652-3" @default.
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