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- W1461331128 abstract "The ability of adeno-associated virus (AAV) to establish a latent infection prompted an investigation of the nature of the viral genome within latently infected cells and led to the discovery that AAV stably integrates with high efficiency into host cell chromatin, with a preponderance of integration events occurring within a specific locus of human chromosome 19 known as AAV integration site 1 (AAVS1). The major open reading frame of the rep gene gives rise to a family of four overlapping nonstructural proteins, known as Rep78, Rep68, Rep52, and Rep40, via a combination of alternative promoter usage and differential utilization of a splicing event. Parallels between the potential chromosomal integration mechanisms of AAV and T-DNA sequences are discussed in detail. Researchers reported the sequence organization of Rep-mediated viral-cellular junctions produced in an in vitro recombination system. Recombination between AAV and cellular sequences at stretches of DNA with significant homology is rarely observed among junctions generated in vivo, and, based on the relatively large copy number of PCR substrates in the in vitro assay, these junctions may have potentially arisen from PCR priming events at Rep binding site (RBS) sequences common to the substrates. The major rescued products were linear duplex molecules with covalently closed ends. Resolution of the integration intermediates described above would use cellular DNA repair mechanisms. Exploration of the phylogenetic relationships among various mobile genetic elements may aid in identifying common mechanisms used in the mobilization and integration of numerous genetic elements of both prokaryotes and eukaryotes." @default.
- W1461331128 created "2016-06-24" @default.
- W1461331128 creator A5012545835 @default.
- W1461331128 creator A5080944120 @default.
- W1461331128 date "2007-07-12" @default.
- W1461331128 modified "2023-10-11" @default.
- W1461331128 title "Adeno‐Associated Virus" @default.
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