Matches in SemOpenAlex for { <https://semopenalex.org/work/W1461661503> ?p ?o ?g. }
- W1461661503 abstract "Stenoses in arterial blood vessels by artherosclerotic processes can decrease the supply of downstream tissue dramatically. The implantation of stents by percutaneous coronary intervention is one method of choice to restore the physiological blood flow. In some cases in-stent re-stenoses by thrombotic events, vascular wall hyperplasia or endothelial dysfunction occur. Causes and nature underlying this processes are not fully understood. Aim of the present study was to study the re-stenotic processes after stent impress on a cellular and molecular level in vitro. Therefore, human arterial endothelial cells (HUAEC) were seeded on a model vascular wall intima consisting of extracellular matrix secreted by bovine corneal endothelial cells. Subsequently, a pre-mounted balloon-expendable tubular stent made of 316 L was impressed through the HUAEC layer leading to an impairment of the vessel wall intima. After stent removal the wound healing process, HUAEC membrane integrity, vitality, proliferation and function were assessed. Immediately after stent impress an increased level of lactate dehydrogenase (LDH) was observed indicating an impairment of the cell membrane integrity. After 24 h baseline LDH values presented again. HUAEC vitality adjacent to the stent impress induced wound was normal (investigated by inverted microscopy). The proliferation of HUAEC was the highest in the direct vicinity of the stent impress induced wound. Prostacyclin and nitric oxide decreased significantly indicating a temporary loss of cell function. These results could imply that the healing process of the endothelial cell lesion is superior to the maintenance of vascular tonicity and downregulation of platelet aggregation." @default.
- W1461661503 created "2016-06-24" @default.
- W1461661503 creator A5024411130 @default.
- W1461661503 creator A5035571325 @default.
- W1461661503 creator A5065284334 @default.
- W1461661503 creator A5091771502 @default.
- W1461661503 date "2015-07-16" @default.
- W1461661503 modified "2023-09-28" @default.
- W1461661503 title "Reaction of arterial endothelial cells to stent impression: In vitro study using a model of the human artery wall" @default.
- W1461661503 cites W1482630306 @default.
- W1461661503 cites W1498704087 @default.
- W1461661503 cites W1568621013 @default.
- W1461661503 cites W1853567728 @default.
- W1461661503 cites W1864920229 @default.
- W1461661503 cites W1978883377 @default.
- W1461661503 cites W1996001348 @default.
- W1461661503 cites W1998644674 @default.
- W1461661503 cites W2007737411 @default.
- W1461661503 cites W2012483466 @default.
- W1461661503 cites W2018641960 @default.
- W1461661503 cites W2021403302 @default.
- W1461661503 cites W2025475810 @default.
- W1461661503 cites W2048635427 @default.
- W1461661503 cites W2054573777 @default.
- W1461661503 cites W2070062282 @default.
- W1461661503 cites W2088760296 @default.
- W1461661503 cites W2089684811 @default.
- W1461661503 cites W2092468599 @default.
- W1461661503 cites W2092481419 @default.
- W1461661503 cites W2105054347 @default.
- W1461661503 cites W2111786317 @default.
- W1461661503 cites W2135968918 @default.
- W1461661503 cites W2141839557 @default.
- W1461661503 cites W2157603347 @default.
- W1461661503 cites W2332144554 @default.
- W1461661503 cites W1495616866 @default.
- W1461661503 doi "https://doi.org/10.3233/jcb-15012" @default.
- W1461661503 hasPublicationYear "2015" @default.
- W1461661503 type Work @default.
- W1461661503 sameAs 1461661503 @default.
- W1461661503 citedByCount "2" @default.
- W1461661503 countsByYear W14616615032017 @default.
- W1461661503 countsByYear W14616615032021 @default.
- W1461661503 crossrefType "journal-article" @default.
- W1461661503 hasAuthorship W1461661503A5024411130 @default.
- W1461661503 hasAuthorship W1461661503A5035571325 @default.
- W1461661503 hasAuthorship W1461661503A5065284334 @default.
- W1461661503 hasAuthorship W1461661503A5091771502 @default.
- W1461661503 hasBestOaLocation W14616615031 @default.
- W1461661503 hasConcept C105702510 @default.
- W1461661503 hasConcept C123012128 @default.
- W1461661503 hasConcept C126322002 @default.
- W1461661503 hasConcept C141071460 @default.
- W1461661503 hasConcept C142724271 @default.
- W1461661503 hasConcept C164705383 @default.
- W1461661503 hasConcept C185592680 @default.
- W1461661503 hasConcept C189165786 @default.
- W1461661503 hasConcept C202751555 @default.
- W1461661503 hasConcept C2776820930 @default.
- W1461661503 hasConcept C2776992346 @default.
- W1461661503 hasConcept C2777339539 @default.
- W1461661503 hasConcept C2777663904 @default.
- W1461661503 hasConcept C2778283817 @default.
- W1461661503 hasConcept C2778583881 @default.
- W1461661503 hasConcept C2779751240 @default.
- W1461661503 hasConcept C2780269544 @default.
- W1461661503 hasConcept C2992686903 @default.
- W1461661503 hasConcept C55493867 @default.
- W1461661503 hasConcept C71924100 @default.
- W1461661503 hasConcept C86803240 @default.
- W1461661503 hasConcept C95444343 @default.
- W1461661503 hasConceptScore W1461661503C105702510 @default.
- W1461661503 hasConceptScore W1461661503C123012128 @default.
- W1461661503 hasConceptScore W1461661503C126322002 @default.
- W1461661503 hasConceptScore W1461661503C141071460 @default.
- W1461661503 hasConceptScore W1461661503C142724271 @default.
- W1461661503 hasConceptScore W1461661503C164705383 @default.
- W1461661503 hasConceptScore W1461661503C185592680 @default.
- W1461661503 hasConceptScore W1461661503C189165786 @default.
- W1461661503 hasConceptScore W1461661503C202751555 @default.
- W1461661503 hasConceptScore W1461661503C2776820930 @default.
- W1461661503 hasConceptScore W1461661503C2776992346 @default.
- W1461661503 hasConceptScore W1461661503C2777339539 @default.
- W1461661503 hasConceptScore W1461661503C2777663904 @default.
- W1461661503 hasConceptScore W1461661503C2778283817 @default.
- W1461661503 hasConceptScore W1461661503C2778583881 @default.
- W1461661503 hasConceptScore W1461661503C2779751240 @default.
- W1461661503 hasConceptScore W1461661503C2780269544 @default.
- W1461661503 hasConceptScore W1461661503C2992686903 @default.
- W1461661503 hasConceptScore W1461661503C55493867 @default.
- W1461661503 hasConceptScore W1461661503C71924100 @default.
- W1461661503 hasConceptScore W1461661503C86803240 @default.
- W1461661503 hasConceptScore W1461661503C95444343 @default.
- W1461661503 hasLocation W14616615031 @default.
- W1461661503 hasOpenAccess W1461661503 @default.
- W1461661503 hasPrimaryLocation W14616615031 @default.
- W1461661503 hasRelatedWork W122936130 @default.
- W1461661503 hasRelatedWork W1840959845 @default.
- W1461661503 hasRelatedWork W1984204348 @default.
- W1461661503 hasRelatedWork W1986724768 @default.