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- W14619407 abstract "Sphingolipids have been suggested to participate in a wide range of cellular processes that are important to growth and differentiation, by functioning as ligands for proteins of the extracellular matrix and cell-cell communication, modulators of the activity of growth factor receptors, lipid second messengers in the action of cytokines and other factors, and as potent activators and inhibitors of cellular regulatory systems such as protein kinase C (as well as other protein kinases and phosphatases), phospholipase C and D, phosphatidic acid phosphatase, and other proteins. For the most part, these roles have been suggested by studies in which specific sphingolipids (e.g., gangliosides, ceramides, sphingosine, and sphingosine 1-phosphate, among others) have been added to cells or enzyme preparations to elicit a response; therefore, the direct involvement of the compounds as regulators of most of these systems in vivo remains to be proven. Nonetheless, a clearer picture is beginning to emerge for three cases, namely: the regulation of the epidermal growth factor receptor by ganglioside GM3, the participation of a sphingomyelin/ceramide cycle in the action of tumor necrosis factor and a number of other agonists, and the disruption of free long-chain (sphin-goid) base metabolism as the mechanism of action of fumonisins and related mycotoxins. These provide models for additional studies of the roles of sphingolipids in the regulation of cellular growth, differentiation, neoplastic transformation, and diverse biological functions." @default.
- W14619407 created "2016-06-24" @default.
- W14619407 creator A5002672605 @default.
- W14619407 creator A5009450265 @default.
- W14619407 creator A5032077625 @default.
- W14619407 date "1996-01-01" @default.
- W14619407 modified "2023-09-25" @default.
- W14619407 title "Sphingolipids as regulators of cellular growth, differentiation, and behavior" @default.
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