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- W146226335 abstract "The nucleoside analog 5-azacytidine (5-aza-C) was first synthesized in Czechoslovakia in 1963 (Piskala and Sorm, 1964); it also has been isolated from streptoverticillium (Streptoverticillus ladakanus, Hanka et al. 1966; Bergy and Herr, 1966). 5-Aza-C differs from cytidine only by the inclusion of a nitrogen atom in the 5 position of the pyrimidine ring (Figure 9.1). It was originally developed for use as a cancer chemotherapeutic agent and is still-used in the treatment of certain types of acute myelogenous leukemia. However, recent interest in the drug has been directed toward its remarkable ability to induce the expression of repressed genes in eukaryotic cells and to act as an inhibitor of DNA methylation." @default.
- W146226335 created "2016-06-24" @default.
- W146226335 creator A5088347458 @default.
- W146226335 date "1984-01-01" @default.
- W146226335 modified "2023-10-14" @default.
- W146226335 title "Gene Activation by 5-Azacytidine" @default.
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- W146226335 doi "https://doi.org/10.1007/978-1-4613-8519-6_9" @default.
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