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• W1462453977 abstract "Catecholamines are metabolized by multiple pathways involving oxidative deamination catalyzed by monoamine oxidase (MAO), O-methylation by catechol O-methyltransferase (COMT) and conjugation by sulfotransferases or glucuronidases. Aldehyde reductase and aldehyde dehydrogenase are other enzymes that participate in sequence with MAO in the production of respective glycol and acid deaminated metabolites. Additionally, alcohol dehydrogenase contributes to formation of homovanillic acid and vanillylmandelic acid (VMA), the final end-products of catecholamine metabolism. This multiplicity of metabolic enzymes ensures redundancy in the mechanisms of catecholamine inactivation and also leads to a wide array of metabolites. The pathways of metabolism depend on compartmentalization of the catabolic enzymes among different cells and tissues. MAO is the sole metabolizing enzyme present in catecholaminergic neurons. The deaminated metabolite of norepinephrine, dihydroxyphenylglycol (DHPG), provides a marker of intraneuronal metabolism. Differences in metabolism among tissues and organs are considered. VMA, the end-product of norepinephrine and epinephrine metabolism and the predominant metabolite excreted in urine, is produced almost exclusively in the liver, mainly from the deaminated metabolites DHPG and 3-methoxy-4-hydroxyphenylglycol. Intraneuronal metabolism is the main determinant of norepinephrine turnover; most of this is dependent on leakage of transmitter from vesicular stores with the contribution from re-uptake only becoming important with increases in exocytotic release. As illustrated in this chapter, studies of catecholamine metabolism provide an ideal contextural framework for bridging molecular biologic, genetic, neurochemical, psychological, and clinical areas of interest. The chapter details oxidative deamination, O-methylation and conjugation of catechol-O-methyltransferase, glucuronidases, and sulphotransferases, and the catecholamine metabolizing systems. The advances described in this section illustrate how the area of catecholamine metabolism offers an ideal context for bridging basic and clinical areas of research. It can be anticipated that future investigation of catecholamine metabolism will continue to provide the conceptual mortar for cementing together integrative understanding of catecholamine systems in health and disease." @default.
• W1462453977 created "2016-06-24" @default.
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• W1462453977 date "1997-01-01" @default.
• W1462453977 modified "2023-10-13" @default.
• W1462453977 title "Catecholamine Metabolism" @default.
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• W1462453977 cites W1967078593 @default.
• W1462453977 cites W1971404174 @default.
• W1462453977 cites W1976415971 @default.
• W1462453977 cites W1982164956 @default.
• W1462453977 cites W1983106271 @default.
• W1462453977 cites W1985095405 @default.
• W1462453977 cites W1987446689 @default.
• W1462453977 cites W1987967410 @default.
• W1462453977 cites W1992648076 @default.
• W1462453977 cites W1993675056 @default.
• W1462453977 cites W1996395058 @default.
• W1462453977 cites W1998480161 @default.
• W1462453977 cites W1998501993 @default.
• W1462453977 cites W2000114256 @default.
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• W1462453977 cites W2002648983 @default.
• W1462453977 cites W2006179567 @default.
• W1462453977 cites W2006264900 @default.
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• W1462453977 cites W2016438049 @default.
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• W1462453977 cites W2023543097 @default.
• W1462453977 cites W2025395195 @default.
• W1462453977 cites W2025642899 @default.
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• W1462453977 cites W2031024794 @default.
• W1462453977 cites W2032848436 @default.
• W1462453977 cites W2034812804 @default.
• W1462453977 cites W2035090455 @default.
• W1462453977 cites W2035722899 @default.
• W1462453977 cites W2036720692 @default.
• W1462453977 cites W2037934133 @default.
• W1462453977 cites W2038043373 @default.
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• W1462453977 cites W2040648960 @default.
• W1462453977 cites W2046008822 @default.
• W1462453977 cites W2047645624 @default.
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• W1462453977 cites W2050654508 @default.
• W1462453977 cites W2053589861 @default.
• W1462453977 cites W2055873198 @default.
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• W1462453977 doi "https://doi.org/10.1016/s1054-3589(08)60746-2" @default.
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