FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W146248421> ?p ?o ?g. }

• W146248421 endingPage "1336" @default.
• W146248421 startingPage "1325" @default.
• W146248421 abstract "The cortical-striatal-thalamic circuit modulates cognitive processing and thus may be involved in the cognitive dysfunction in schizophrenia. The imaging of metabolic rate in the structures making up this circuit could reveal the correlates of schizophrenia and its main symptoms.Seventy male schizophrenic patients underwent [18F]-fluorodeoxyglucose positron emission tomography after a period of at least 4 weeks during which they had not received neuroleptic medication and were compared to 30 age-matched male normal comparison subjects.Analyses revealed decreased metabolism in medial frontal cortex, cingulate gyrus, medial temporal lobe, corpus callosum, and ventral caudate and increased metabolism in the left lateral temporal and occipital cortices in the schizophrenic cohort. Consistent with previous studies, the schizophrenic group had lower hypofrontality scores (ratios of lateral frontal to occipital metabolism) than did comparison subjects. The lateral frontal cortical metabolism of schizophrenic patients did not differ from that of comparison subjects, while occipital cortical metabolism was high, suggesting that lateral hypofrontality is due to abnormalities in occipital rather than lateral frontal activity. Hypofrontality was more prominent in medial than lateral frontal cortex. Brief Psychiatric Rating Scale (BPRS) scores, obtained for each schizophrenic patient on the scan day, were correlated with regional brain glucose metabolic rate. Medial frontal cortical and thalamic activity correlated negatively with total BPRS score and with positive and negative symptom scores. Lateral frontal cortical metabolism and hypofrontality scores did not significantly correlate with negative symptoms. Analyses of variance demonstrated a reduced right greater than left asymmetry in the schizophrenic patients for the lateral cortex as a whole, with simple interactions showing this effect specifically in temporal and frontal cortical regions.Low metabolic rates were confirmed in medial frontal cortical regions as well as in the basal ganglia, consistent with the importance of the cortical-striatal-thalamic pathways in schizophrenia. Loss of normal lateralization patterns was also observed on an exploratory basis. Correlations with negative symptoms and group differences were more prominent in medial than lateral frontal cortex, suggesting that medial regions may be more important in schizophrenic pathology." @default.
• W146248421 created "2016-06-24" @default.
• W146248421 creator A5003010692 @default.
• W146248421 creator A5028087155 @default.
• W146248421 creator A5038907091 @default.
• W146248421 creator A5042023490 @default.
• W146248421 creator A5044189336 @default.
• W146248421 creator A5050834331 @default.
• W146248421 creator A5054827230 @default.
• W146248421 creator A5067023244 @default.
• W146248421 creator A5082310153 @default.
• W146248421 creator A5083292558 @default.
• W146248421 date "1993-09-01" @default.
• W146248421 modified "2023-10-06" @default.
• W146248421 title "Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients" @default.
• W146248421 doi "https://doi.org/10.1176/ajp.150.9.1325" @default.
• W146248421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8352343" @default.
• W146248421 hasPublicationYear "1993" @default.
• W146248421 type Work @default.
• W146248421 sameAs 146248421 @default.
• W146248421 citedByCount "194" @default.
• W146248421 countsByYear W1462484212012 @default.
• W146248421 countsByYear W1462484212013 @default.
• W146248421 countsByYear W1462484212014 @default.
• W146248421 countsByYear W1462484212015 @default.
• W146248421 countsByYear W1462484212016 @default.
• W146248421 countsByYear W1462484212017 @default.
• W146248421 countsByYear W1462484212019 @default.
• W146248421 countsByYear W1462484212021 @default.
• W146248421 countsByYear W1462484212022 @default.
• W146248421 crossrefType "journal-article" @default.
• W146248421 hasAuthorship W146248421A5003010692 @default.
• W146248421 hasAuthorship W146248421A5028087155 @default.
• W146248421 hasAuthorship W146248421A5038907091 @default.
• W146248421 hasAuthorship W146248421A5042023490 @default.
• W146248421 hasAuthorship W146248421A5044189336 @default.
• W146248421 hasAuthorship W146248421A5050834331 @default.
• W146248421 hasAuthorship W146248421A5054827230 @default.
• W146248421 hasAuthorship W146248421A5067023244 @default.
• W146248421 hasAuthorship W146248421A5082310153 @default.
• W146248421 hasAuthorship W146248421A5083292558 @default.
• W146248421 hasConcept C118552586 @default.
• W146248421 hasConcept C15744967 @default.
• W146248421 hasConcept C169760540 @default.
• W146248421 hasConcept C2776412080 @default.
• W146248421 hasConcept C2777127467 @default.
• W146248421 hasConcept C2778046553 @default.
• W146248421 hasConcept C2778183499 @default.
• W146248421 hasConcept C2778186239 @default.
• W146248421 hasConcept C2778528637 @default.
• W146248421 hasConcept C2779369059 @default.
• W146248421 hasConcept C2779727114 @default.
• W146248421 hasConcept C2781099131 @default.
• W146248421 hasConcept C2781423529 @default.
• W146248421 hasConceptScore W146248421C118552586 @default.
• W146248421 hasConceptScore W146248421C15744967 @default.
• W146248421 hasConceptScore W146248421C169760540 @default.
• W146248421 hasConceptScore W146248421C2776412080 @default.
• W146248421 hasConceptScore W146248421C2777127467 @default.
• W146248421 hasConceptScore W146248421C2778046553 @default.
• W146248421 hasConceptScore W146248421C2778183499 @default.
• W146248421 hasConceptScore W146248421C2778186239 @default.
• W146248421 hasConceptScore W146248421C2778528637 @default.
• W146248421 hasConceptScore W146248421C2779369059 @default.
• W146248421 hasConceptScore W146248421C2779727114 @default.
• W146248421 hasConceptScore W146248421C2781099131 @default.
• W146248421 hasConceptScore W146248421C2781423529 @default.
• W146248421 hasIssue "9" @default.
• W146248421 hasLocation W1462484211 @default.
• W146248421 hasLocation W1462484212 @default.
• W146248421 hasOpenAccess W146248421 @default.
• W146248421 hasPrimaryLocation W1462484211 @default.
• W146248421 hasRelatedWork W146248421 @default.
• W146248421 hasRelatedWork W1970978867 @default.
• W146248421 hasRelatedWork W1983956215 @default.
• W146248421 hasRelatedWork W2041923716 @default.
• W146248421 hasRelatedWork W2080846674 @default.
• W146248421 hasRelatedWork W2157033569 @default.
• W146248421 hasRelatedWork W2350970671 @default.
• W146248421 hasRelatedWork W2377925718 @default.
• W146248421 hasRelatedWork W4246587052 @default.
• W146248421 hasRelatedWork W2483534075 @default.
• W146248421 hasVolume "150" @default.
• W146248421 isParatext "false" @default.
• W146248421 isRetracted "false" @default.
• W146248421 magId "146248421" @default.
• W146248421 workType "article" @default.