Matches in SemOpenAlex for { <https://semopenalex.org/work/W146280905> ?p ?o ?g. }
- W146280905 endingPage "292" @default.
- W146280905 startingPage "283" @default.
- W146280905 abstract "This chapter reviews the biology of the leukotrienes (LTB4, LTC4, LTD4, and LTE4) and lipoxins (LXA4 and LXB4), which are molecules derived by lipoxygenation of arachidonic acid. It explores the role of leukotrienes and lipoxins in bronchial asthma and chronic obstructive pulmonary disease (COPD). They are produced by constitutive cells, like mast cells/ macrophages) and infiltrating cells (eosinophils, neutrophils) implicated in asthma and COPD. Laboratory-induced asthma and spontaneous asthma or COPD is associated with an enhanced recovery of leukotrienes in the urine and exhaled breath condensate of subjects with asthma and sputum, BAL or exhaled breath condensate leukotrienes in COPD. They are potent bronchoconstrictor agonists. Their administration results in the expression of mucus from mucous glands. Agents capable of interfering with leukotriene action or synthesis enhance asthma control. Similar data are not available for COPD. The data indicate that the leukotrienes play an important role in the asthmatic response. But the importance of the pathogenetic role of the leukotrienes in COPD is still not known. Lipoxins are generated in respiratory tissues in asthma and COPD and can decrease airway inflammation and hyperresponsiveness in laboratory-induced asthma. Since these data are not biologically informative with respect to the role the leukotrienes in COPD, larger better-controlled studies are needed to resolve this issue." @default.
- W146280905 created "2016-06-24" @default.
- W146280905 creator A5050132863 @default.
- W146280905 creator A5080604474 @default.
- W146280905 date "2009-01-01" @default.
- W146280905 modified "2023-09-26" @default.
- W146280905 title "Leukotrienes and Lipoxins" @default.
- W146280905 cites W140981747 @default.
- W146280905 cites W1486027616 @default.
- W146280905 cites W1488413741 @default.
- W146280905 cites W1488738675 @default.
- W146280905 cites W1497700962 @default.
- W146280905 cites W1503449755 @default.
- W146280905 cites W1531140346 @default.
- W146280905 cites W1544939802 @default.
- W146280905 cites W1552747622 @default.
- W146280905 cites W1573902696 @default.
- W146280905 cites W1762177519 @default.
- W146280905 cites W1857351336 @default.
- W146280905 cites W1890023926 @default.
- W146280905 cites W1913937884 @default.
- W146280905 cites W1915136464 @default.
- W146280905 cites W1936798053 @default.
- W146280905 cites W1963981548 @default.
- W146280905 cites W1964579607 @default.
- W146280905 cites W1966982430 @default.
- W146280905 cites W1967231335 @default.
- W146280905 cites W1967577821 @default.
- W146280905 cites W1972134778 @default.
- W146280905 cites W1982283061 @default.
- W146280905 cites W1982558653 @default.
- W146280905 cites W1982778295 @default.
- W146280905 cites W1985414959 @default.
- W146280905 cites W1986483382 @default.
- W146280905 cites W1986734670 @default.
- W146280905 cites W1988831361 @default.
- W146280905 cites W1989076522 @default.
- W146280905 cites W1991857563 @default.
- W146280905 cites W1994604019 @default.
- W146280905 cites W1994825511 @default.
- W146280905 cites W1995245953 @default.
- W146280905 cites W1995529555 @default.
- W146280905 cites W2001078226 @default.
- W146280905 cites W2002058751 @default.
- W146280905 cites W2002351007 @default.
- W146280905 cites W2004593577 @default.
- W146280905 cites W2004920998 @default.
- W146280905 cites W2006888325 @default.
- W146280905 cites W2007323623 @default.
- W146280905 cites W2012038221 @default.
- W146280905 cites W2013630056 @default.
- W146280905 cites W2014768234 @default.
- W146280905 cites W2015143997 @default.
- W146280905 cites W2015332855 @default.
- W146280905 cites W2015677100 @default.
- W146280905 cites W2018428175 @default.
- W146280905 cites W2019443108 @default.
- W146280905 cites W2021905899 @default.
- W146280905 cites W2022724314 @default.
- W146280905 cites W2022942716 @default.
- W146280905 cites W2024176341 @default.
- W146280905 cites W2026463427 @default.
- W146280905 cites W2029251290 @default.
- W146280905 cites W2029493882 @default.
- W146280905 cites W2037147625 @default.
- W146280905 cites W2037179116 @default.
- W146280905 cites W2037371724 @default.
- W146280905 cites W2039802351 @default.
- W146280905 cites W2040062751 @default.
- W146280905 cites W2040526845 @default.
- W146280905 cites W2040827725 @default.
- W146280905 cites W2042324713 @default.
- W146280905 cites W2043811030 @default.
- W146280905 cites W2045011622 @default.
- W146280905 cites W2045785028 @default.
- W146280905 cites W2046698459 @default.
- W146280905 cites W2051793746 @default.
- W146280905 cites W2052828945 @default.
- W146280905 cites W2054596484 @default.
- W146280905 cites W2056490803 @default.
- W146280905 cites W2056574594 @default.
- W146280905 cites W2056908250 @default.
- W146280905 cites W2057134129 @default.
- W146280905 cites W2058661991 @default.
- W146280905 cites W2059429399 @default.
- W146280905 cites W2065226504 @default.
- W146280905 cites W2065308194 @default.
- W146280905 cites W2065376096 @default.
- W146280905 cites W2066950125 @default.
- W146280905 cites W2067436474 @default.
- W146280905 cites W2067595559 @default.
- W146280905 cites W2070740222 @default.
- W146280905 cites W2071201771 @default.
- W146280905 cites W2073202677 @default.
- W146280905 cites W2077251970 @default.
- W146280905 cites W2077274868 @default.
- W146280905 cites W2077575132 @default.
- W146280905 cites W2079362874 @default.