FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1463238666> ?p ?o ?g. }

• W1463238666 endingPage "111" @default.
• W1463238666 startingPage "101" @default.
• W1463238666 abstract "An HIV-1 infection in a host cell occurs through an ordered process that involves HIV-1 attachment to the host's cellular CD4 receptor, co-receptor binding to CCR5 or CXCR4, and the subsequent fusion with the cellular membrane. The natural viral entry pathway into a host cell provides an opportunity to develop agents for the treatment of HIV-1 infections. Several engineered monoclonal antibodies specifically targeting CD4 have shown antiviral activities in clinical trials. Here, we report on an anti-CD4 mAb (15A7) that displays a unique binding specificity for domain 1 of CD4, whose epitope partially overlaps with the gp120 binding region. Moreover, 15A7 displays a much stronger binding affinity to CD4(+) cell lines after HIV infection. 15A7 is able to block and neutralize a broad range of primary HIV-1 isolates and T cell-line passage strains. Notably, the bivalent F(ab')2 form of 15A7 is more effective than the Fab form in blocking HIV-1 infection, which is further supported by molecular docking analyses. Together, these results suggest that this novel antibody may exert its antiviral activity by blocking gp120 targeting to the CD4 receptor or competing with gp120 for CD4 receptor binding and might present post-attachment neutralization activity. This antibody could provide a new candidate to efficiently block HIV-1 infection or provide new starting materials for HIV treatment, especially when HIV-1-resistant strains against the current CD4 mAb treatments have already been identified." @default.
• W1463238666 created "2016-06-24" @default.
• W1463238666 creator A5005402819 @default.
• W1463238666 creator A5013807832 @default.
• W1463238666 creator A5014233085 @default.
• W1463238666 creator A5019194793 @default.
• W1463238666 creator A5021873093 @default.
• W1463238666 creator A5025014622 @default.
• W1463238666 creator A5033679543 @default.
• W1463238666 creator A5049645907 @default.
• W1463238666 creator A5067654958 @default.
• W1463238666 creator A5070168366 @default.
• W1463238666 creator A5080770831 @default.
• W1463238666 creator A5088393966 @default.
• W1463238666 date "2015-10-01" @default.
• W1463238666 modified "2023-09-24" @default.
• W1463238666 title "Molecular insights into the inhibition of HIV-1 infection using a CD4 domain-1-specific monoclonal antibody" @default.
• W1463238666 cites W1554980524 @default.
• W1463238666 cites W1556988007 @default.
• W1463238666 cites W1628484047 @default.
• W1463238666 cites W1883213496 @default.
• W1463238666 cites W1965052190 @default.
• W1463238666 cites W1971057735 @default.
• W1463238666 cites W1976125224 @default.
• W1463238666 cites W1978398372 @default.
• W1463238666 cites W1978913715 @default.
• W1463238666 cites W1988501494 @default.
• W1463238666 cites W1989174077 @default.
• W1463238666 cites W1992566288 @default.
• W1463238666 cites W1993366615 @default.
• W1463238666 cites W1994982043 @default.
• W1463238666 cites W1997677784 @default.
• W1463238666 cites W2009611825 @default.
• W1463238666 cites W2015229271 @default.
• W1463238666 cites W2024608724 @default.
• W1463238666 cites W2025915045 @default.
• W1463238666 cites W2028834214 @default.
• W1463238666 cites W2029135056 @default.
• W1463238666 cites W2031542973 @default.
• W1463238666 cites W2037320559 @default.
• W1463238666 cites W2040239455 @default.
• W1463238666 cites W2047775965 @default.
• W1463238666 cites W2063880503 @default.
• W1463238666 cites W2067694850 @default.
• W1463238666 cites W2079355826 @default.
• W1463238666 cites W2089562940 @default.
• W1463238666 cites W2091051563 @default.
• W1463238666 cites W2093582005 @default.
• W1463238666 cites W2094180923 @default.
• W1463238666 cites W2094750078 @default.
• W1463238666 cites W2095651963 @default.
• W1463238666 cites W2101406373 @default.
• W1463238666 cites W2102534628 @default.
• W1463238666 cites W2102548388 @default.
• W1463238666 cites W2104152050 @default.
• W1463238666 cites W2104318155 @default.
• W1463238666 cites W2108096886 @default.
• W1463238666 cites W2113282092 @default.
• W1463238666 cites W2119289853 @default.
• W1463238666 cites W2126255146 @default.
• W1463238666 cites W2130480117 @default.
• W1463238666 cites W2134312805 @default.
• W1463238666 cites W2135747811 @default.
• W1463238666 cites W2137535177 @default.
• W1463238666 cites W2143104279 @default.
• W1463238666 cites W2143504816 @default.
• W1463238666 cites W2143585030 @default.
• W1463238666 cites W2146478787 @default.
• W1463238666 cites W2154933804 @default.
• W1463238666 cites W2155892284 @default.
• W1463238666 cites W2162671566 @default.
• W1463238666 cites W2165712302 @default.
• W1463238666 cites W2167786748 @default.
• W1463238666 cites W2170217766 @default.
• W1463238666 cites W2171527994 @default.
• W1463238666 cites W2328163716 @default.
• W1463238666 cites W303439820 @default.
• W1463238666 doi "https://doi.org/10.1016/j.antiviral.2015.08.004" @default.
• W1463238666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26259811" @default.
• W1463238666 hasPublicationYear "2015" @default.
• W1463238666 type Work @default.
• W1463238666 sameAs 1463238666 @default.
• W1463238666 citedByCount "6" @default.
• W1463238666 countsByYear W14632386662016 @default.
• W1463238666 countsByYear W14632386662019 @default.
• W1463238666 countsByYear W14632386662021 @default.
• W1463238666 countsByYear W14632386662022 @default.
• W1463238666 crossrefType "journal-article" @default.
• W1463238666 hasAuthorship W1463238666A5005402819 @default.
• W1463238666 hasAuthorship W1463238666A5013807832 @default.
• W1463238666 hasAuthorship W1463238666A5014233085 @default.
• W1463238666 hasAuthorship W1463238666A5019194793 @default.
• W1463238666 hasAuthorship W1463238666A5021873093 @default.
• W1463238666 hasAuthorship W1463238666A5025014622 @default.
• W1463238666 hasAuthorship W1463238666A5033679543 @default.
• W1463238666 hasAuthorship W1463238666A5049645907 @default.
• W1463238666 hasAuthorship W1463238666A5067654958 @default.
• W1463238666 hasAuthorship W1463238666A5070168366 @default.

• next