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- W146356952 endingPage "975" @default.
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- W146356952 abstract "The cytoskeleton in keratinocytes is a complex of highly homologous structural proteins derived from two families of type I and type II polypeptides. Keratin K2e is a type II polypeptide that is expressed in epidermis late in differentiation. Here we report the influence of keratinocyte activation, proliferation, and keratinization on K2e expression in samples of cutaneous and oral lesions. The normal expression of K2e in the upper spinous and granular layers of interfollicular epidermis is increased in keloid scars but showed distinct down-regulation in psoriasis and hypertrophic scars where keratinocytes are known to undergo activation. Unlike normal and psoriatic skin, K2e expression in hypertrophic and keloid scars began in the deepest suprabasal layer. In cutaneous basal and squamous cell carcinomas, K2e was absent in most tumor islands but the overlying epidermis showed strong expression. No significant K2e expression in nonkeratinized or keratinized oral epithelia, including buccal mucosa, lateral border of tongue and gingiva was detected. In oral lichen planus K2e expression was undetectable, but in benign keratoses of lingual mucosa induction of K2e along with K1 and K10 was observed. In mild-to-moderate oral dysplasia with orthokeratinization, K2e was highly expressed compared with parakeratinized areas but in severe dysplasia as well as in oral squamous cell carcinoma, K2e expression was undetectable. Taken together, the data suggest that K2e expression in skin is sensitive to keratinocyte activation but its up-regulation in oral lesions is a reflection of the degree of orthokeratinization." @default.
- W146356952 created "2016-06-24" @default.
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- W146356952 date "2003-03-01" @default.
- W146356952 modified "2023-09-27" @default.
- W146356952 title "Expression of Keratin K2e in Cutaneous and Oral Lesions" @default.
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- W146356952 cites W1944130357 @default.
- W146356952 cites W1958586460 @default.
- W146356952 cites W1969238404 @default.
- W146356952 cites W1978411073 @default.
- W146356952 cites W1978875825 @default.
- W146356952 cites W1981439710 @default.
- W146356952 cites W1989021197 @default.
- W146356952 cites W1995891446 @default.
- W146356952 cites W2009462949 @default.
- W146356952 cites W2009536539 @default.
- W146356952 cites W201033154 @default.
- W146356952 cites W2010780067 @default.
- W146356952 cites W2011824801 @default.
- W146356952 cites W2012957720 @default.
- W146356952 cites W2013096956 @default.
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- W146356952 cites W2017645440 @default.
- W146356952 cites W2019535031 @default.
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- W146356952 cites W2024851131 @default.
- W146356952 cites W2028852297 @default.
- W146356952 cites W2030491152 @default.
- W146356952 cites W2031504007 @default.
- W146356952 cites W2033129194 @default.
- W146356952 cites W2036634303 @default.
- W146356952 cites W2036733592 @default.
- W146356952 cites W2038013281 @default.
- W146356952 cites W2047423042 @default.
- W146356952 cites W2056349938 @default.
- W146356952 cites W2059032249 @default.
- W146356952 cites W2059295317 @default.
- W146356952 cites W2061047163 @default.
- W146356952 cites W2062300120 @default.
- W146356952 cites W2065303354 @default.
- W146356952 cites W2070952971 @default.
- W146356952 cites W2070995184 @default.
- W146356952 cites W2071454845 @default.
- W146356952 cites W2074592444 @default.
- W146356952 cites W2076270502 @default.
- W146356952 cites W2077558523 @default.
- W146356952 cites W2081743971 @default.
- W146356952 cites W2082873974 @default.
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- W146356952 cites W2128311245 @default.
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- W146356952 cites W2135041211 @default.
- W146356952 cites W2137541387 @default.
- W146356952 cites W2141021726 @default.
- W146356952 cites W2175920363 @default.
- W146356952 cites W2411627258 @default.
- W146356952 cites W2434496826 @default.
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- W146356952 doi "https://doi.org/10.1016/s0002-9440(10)63891-6" @default.
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