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• W1463669810 abstract "This chapter analyzes data concerning the metabolic fate of various classes of therapeutic agents. Agents affecting the central nervous system (CNS), particularly psychoactive agents, appear to be the most frequently studied compounds. Perazine underwent a series of metabolic transformations similar to those previously reported for other phenothiazines. Urine recovered from schizophrenic patients dosed with perazine contained N-oxide derivatives as the major nonhydroxylated metabolites, whereas this was not the case for chlorpromazine. During treatment with perazine, patients exhibited a consistent increase in the demethylated products relative to the corresponding tertiary amines, a finding attributed to the possible induction of a liver microsomal demethylase. At least 20 metabolites of imipramine excreted in human urine were identified by two-dimensional thin layer chromatography. These metabolites resulted from a combination of mono- or di-demethylation or dealkylation of the side chain and hydroxylation at the 2 or 10 positions with subsequent conjugation. The metabolism of quinidine, a naturally occurring alkaloid with antiarrhythmic properties, was studied in man as the gluconate salt. Metabolites isolated from urine were found to be oxygenated on either the quinoline or quinuclidine portions of the molecule, and uncharacterized polyoxygenated derivatives were also found." @default.
• W1463669810 created "2016-06-24" @default.
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• W1463669810 date "1970-01-01" @default.
• W1463669810 modified "2023-09-25" @default.
• W1463669810 title "Chapter 22. Drug Metabolism" @default.
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• W1463669810 doi "https://doi.org/10.1016/s0065-7743(08)60345-0" @default.
• W1463669810 hasPublicationYear "1970" @default.
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