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• W1463735117 abstract "To examine endocrine and clinical responses to long-term administration of RU486 in patients with endometriosis. Prospective open trial. Faculty practice of the authors. Six normally cycling women with endometriosis were recruited. Subjects received RU486 100 mg/d for 3 months. Hormonal changes during RU486 were compared with control data obtained in the preceding cycle during the early follicular phase. Clinical responses were determined by patient assessment and second-look laparoscopy. All women became amenorrheic, and daily urinary levels of ovarian steroid metabolites remained acyclic. Mean luteinizing hormone (LH) (P < 0.02) and LH pulse amplitude (P < 0.05) were increased without changes in LH pulse frequency. An antiglucocorticoid effect was demonstrated by an increase in serum cortisol (P < 0.01) and adrenocorticotropic hormone (P < 0.05) levels. Treatment resulted in an improvement in pelvic pain in all subjects without significant change in the extent of disease as evaluated by follow-up laparoscopy. Daily administration of RU486 results in acyclic ovarian function and improvement in the subjective painful symptoms of endometriosis." @default.
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• W1463735117 date "1991-09-01" @default.
• W1463735117 modified "2023-09-29" @default.
• W1463735117 title "Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis" @default.
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• W1463735117 doi "https://doi.org/10.1016/s0015-0282(16)54531-2" @default.
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