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- W146501041 abstract "Publisher SummaryThis chapter analyzes the clinical manifestations of the obstetrical antiphospholipid syndrome (APS) and reviews the pathophysiology of the obstetrical complications related with the APS. The most characteristic feature of obstetrical APS is pregnancy loss. However, aPL antibodies are also associated with a number of other serious obstetric complications including pre-eclampsia, fetal growth restriction, utero-placental insufficiency, fetal distress, and medically induced preterm birth. All these complications can be associated with serious maternal consequences. Pre-eclampsia is an obstetric complication defined as the occurrence of hypertension and proteinuria after 20 weeks gestation in a previously normotensive woman. The rate of aparition of pre-eclampsia in unselected pregnancies ranges between 2% and 10%. The risk for thrombosis has also been reported to be high in pregnant patients with APS. The risk of thrombosis seems to be lower in women with low levels of aCL or without LA. The close association of aPL with fetal death and obstetrical complications suggests a causative role. Utero-placental insufficiency is often attributed to vasculopathy of the terminal spiral arteries which nourish the placentary intervillous space. In fact, fetal death in APS is usually preceded by fetal growth retardation, olygohidramnios and doppler alteration of the feto-placental circulation, reflecting fetal hypoxia and placental dysfunction.." @default.
- W146501041 created "2016-06-24" @default.
- W146501041 creator A5037913108 @default.
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- W146501041 date "2002-01-01" @default.
- W146501041 modified "2023-10-16" @default.
- W146501041 title "Fetal and Obstetric Manifestations and Infertility in the Antiphospholipid Syndrome" @default.
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- W146501041 doi "https://doi.org/10.1016/b978-044450987-1/50022-x" @default.
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