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• W1465302203 abstract "Several facts enticed the author to look beyond Borrelia for undocumented prophages in other bacterial genome sequences. At the beginning the author was very uncertain about whether there would be any interest in prophages or, on the other hand, whether the prophage abundance he was finding was considered to already be known and thus boring. In addition to fully intact prophages, many bacterial genomes harbor defective prophages that have suffered deletions of genes essential for full phage functionality. The Salmonella prophages, whose genomic locations are shown in this chapter, are in fact very instructive cases. A curious observation regarding the prophages is that the genome-wide screen of Lawley and others for genes that are required for long-term systemic infection of the mouse was answered by mutations in (among many others) genes that encode virion assembly proteins in five of the above prophages. The remaining possibly phage-related genes in the LT2 chromosome consist of a few other fragmentary integrase-like sequences and phage lysis-like genes. These could be the remains of otherwise essentially completely deleted prophages, but the former could also be from other types of mobile elements. Another interesting feature that emerged from early prophage surveys was the fact that different isolates of the same bacterial species often have quite different prophage contents, indicating that prophages are coming and going rather quickly on the overall evolutionary scale." @default.
• W1465302203 created "2016-06-24" @default.
• W1465302203 creator A5081637587 @default.
• W1465302203 date "2014-04-09" @default.
• W1465302203 modified "2023-09-28" @default.
• W1465302203 title "A Plethora of Putative Phages and Prophages" @default.
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• W1465302203 doi "https://doi.org/10.1128/9781555816810.ch29" @default.
• W1465302203 hasPublicationYear "2014" @default.
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