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- W14656570 abstract "ABSTRACT Objective : The purpose of this study is to compare anti-thrombotic activities of 4 Rhubarb species.Methods : Rhubarb has been used as medical and edible resources worldwide for the therapy of cancer, constipation and inflammation, etc. To compare the anti-thrombotic activities among the species within rhubarb, we investigated and compared the inhibitory properties of water extracts from R. palmatum(RPE), R. officinale(ROE), R. nobile(RNE), and R. franzenbachii(RFE) on the fibrinolysis, blood coagulation and platelet aggregation. APTT and PT, blood coagulation time, were measured by apparatus of auto blood coagulation analysis that called ACL-7000. The measurement of fibrinolysis was measured and compares with the width of clear zone from melted fibrin plate. The platelet aggregation w as measured and compared with inhibition rate of aggregation.Results : We found out the best species from rhubarb showing the signifi cant fibrinolytic, anti-coagulant and anti-platelet aggregation activity. Our results show that Rheum nobile (RNE) has the most effective anti-thrombotic activity among 4 tested rhubarb.Conclusions : This study, therefore, RNE will be able to be used the development of drug which is thrombosis treatment.Key Words : Anti-Thrombotic; Platelet Aggregation; Rheum palmatum; Rheum officinale; Rheum nobile; Rheum franzenbachii" @default.
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- W14656570 date "2010-01-01" @default.
- W14656570 modified "2023-09-26" @default.
- W14656570 title "Comparative Study of Extracts from Rhubarb on Anti-Thrombotic and Anti-Platelet Activity" @default.
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- W14656570 doi "https://doi.org/10.6116/kjh.2010.25.4.001" @default.
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