FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W14658192> ?p ?o ?g. }

• W14658192 endingPage "292" @default.
• W14658192 startingPage "257" @default.
• W14658192 abstract "Cardiovascular disease is the major cause of death in patients with renal insufficiency, accounting for 50% of all deaths in renal replacement therapy patients and in recipients of renal transplants. Mortality from cardiovascular diseases in patients with renal failure is approximately 9% per year, which is about 30 times the risk in the general population. Evidence has emerged pointing to a potential role of oxidative stress in generation of advanced glycation end products (AGEs) in patients with end stage renal disease (ESRD). Moreover, interaction of the receptor for AGEs (RAGE) with AGEs leads to crucial biomedical pathway, generating intracellular oxidative stress and inflammatory mediators, which could result in further amplification of the pathway involved in AGE generation. AGEs and RAGE can profoundly be involved in cardiovascular diseases through regulation of (a) atherogenesis, (b) angiogenic response, (c) vascular injury, and (d) inflammatory response. Recently, numerous truncated forms of RAGE have been described, and the C-terminally truncated soluble form of RAGE has received much attention. Soluble RAGE consists of several forms including endogenous secretory RAGE (esRAGE), which is a spliced variant of RAGE, and a shedded form derived from cell surface RAGE. These heterogeneous forms of soluble RAGE, carrying all of the extracellular domains but devoid of the transmembrane and intracytoplasmic domains, bind ligands including AGEs and are capable of antagonizing RAGE signaling in vitro and in vivo. Enzyme-linked immunosorbent assay (ELISA) systems to measure plasma esRAGE and total soluble RAGE have been developed, and the pathophysiological roles of soluble RAGE have begun to be unveiled clinically. In this chapter, we will summarize the recent findings of AGEs/RAGE/soluble RAGE axis as a crucial mediator of oxidative stress and cardiovascular disease and discuss their potential usefulness as therapeutic targets and biomarkers for the disease." @default.
• W14658192 created "2016-06-24" @default.
• W14658192 creator A5033341908 @default.
• W14658192 creator A5067176715 @default.
• W14658192 date "2010-11-22" @default.
• W14658192 modified "2023-09-26" @default.
• W14658192 title "Cardiovascular Complications in Renal Failure: Implications of Advanced Glycation End Products and Their Receptor RAGE" @default.
• W14658192 cites W1207588145 @default.
• W14658192 cites W1207740807 @default.
• W14658192 cites W1485299080 @default.
• W14658192 cites W1520402836 @default.
• W14658192 cites W1582132429 @default.
• W14658192 cites W1964395052 @default.
• W14658192 cites W1966780233 @default.
• W14658192 cites W1966813043 @default.
• W14658192 cites W1968233853 @default.
• W14658192 cites W1968299608 @default.
• W14658192 cites W1970255672 @default.
• W14658192 cites W1971209988 @default.
• W14658192 cites W1972459018 @default.
• W14658192 cites W1975084348 @default.
• W14658192 cites W1976616659 @default.
• W14658192 cites W1978718183 @default.
• W14658192 cites W1978793468 @default.
• W14658192 cites W1979103623 @default.
• W14658192 cites W1982914851 @default.
• W14658192 cites W1984830754 @default.
• W14658192 cites W1985236743 @default.
• W14658192 cites W1985327918 @default.
• W14658192 cites W1985365252 @default.
• W14658192 cites W1985775184 @default.
• W14658192 cites W1987703665 @default.
• W14658192 cites W1987796811 @default.
• W14658192 cites W1988264102 @default.
• W14658192 cites W1989321457 @default.
• W14658192 cites W1989362485 @default.
• W14658192 cites W1990365963 @default.
• W14658192 cites W1992380078 @default.
• W14658192 cites W1992484293 @default.
• W14658192 cites W1995038226 @default.
• W14658192 cites W1995707828 @default.
• W14658192 cites W1996479665 @default.
• W14658192 cites W1997604729 @default.
• W14658192 cites W1998181190 @default.
• W14658192 cites W1999684267 @default.
• W14658192 cites W2000281764 @default.
• W14658192 cites W2001320633 @default.
• W14658192 cites W2005869447 @default.
• W14658192 cites W2008826807 @default.
• W14658192 cites W2010913383 @default.
• W14658192 cites W2011382030 @default.
• W14658192 cites W2011988431 @default.
• W14658192 cites W2012772537 @default.
• W14658192 cites W2013180282 @default.
• W14658192 cites W2013730613 @default.
• W14658192 cites W2016370501 @default.
• W14658192 cites W2018620079 @default.
• W14658192 cites W2019656247 @default.
• W14658192 cites W2021289068 @default.
• W14658192 cites W2021346724 @default.
• W14658192 cites W2022356903 @default.
• W14658192 cites W2022660459 @default.
• W14658192 cites W2023427279 @default.
• W14658192 cites W2023555122 @default.
• W14658192 cites W2024543272 @default.
• W14658192 cites W2025174396 @default.
• W14658192 cites W2027604422 @default.
• W14658192 cites W2027944101 @default.
• W14658192 cites W2029864685 @default.
• W14658192 cites W2031215872 @default.
• W14658192 cites W2031234071 @default.
• W14658192 cites W2031314136 @default.
• W14658192 cites W2038528673 @default.
• W14658192 cites W2038792388 @default.
• W14658192 cites W2041712533 @default.
• W14658192 cites W2042667331 @default.
• W14658192 cites W2042761977 @default.
• W14658192 cites W2042854938 @default.
• W14658192 cites W2043296623 @default.
• W14658192 cites W2047168177 @default.
• W14658192 cites W2047571038 @default.
• W14658192 cites W2047873996 @default.
• W14658192 cites W2048544704 @default.
• W14658192 cites W2049167261 @default.
• W14658192 cites W2049796621 @default.
• W14658192 cites W2052013968 @default.
• W14658192 cites W2052746932 @default.
• W14658192 cites W2053704719 @default.
• W14658192 cites W2056258976 @default.
• W14658192 cites W2057683168 @default.
• W14658192 cites W2059229152 @default.
• W14658192 cites W2059736408 @default.
• W14658192 cites W2060368510 @default.
• W14658192 cites W2062273929 @default.
• W14658192 cites W2062930842 @default.
• W14658192 cites W2065012620 @default.
• W14658192 cites W2066509637 @default.
• W14658192 cites W2066779642 @default.

• next