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- W1465907849 abstract "Abstract In recent years, dendritic cells derived from monocytes (mo-DC) have been extensively studied as novel cell-therapeutic candidates for the treatment of various tumors. In order to elicit tumor-specific CTL responses, DC need to be capable of cross-presenting antigens. Recently, the serine protease granzyme B (GrB) was found to be crucially involved in cleavage and cross-presentation of antigens. We therefore hypothesized that monocytes may be able to express GrB under certain circumstances, comparable to other DC precursors including mDC and pDC. Using various methods including FACS analysis, ELISpot and Western immunoblot we found that monocytes can express GrB depending on various external stimuli. Importantly, we found that the TLR4 ligand LPS appears to play a central role in the induction of GrB in monocytes, and that the presence of antigen-stimulated B cells synergistically enhances GrB expression in monocytes. Moreover, when maturing monocytes into mo-DC, the IL-2 family cytokine IL-7 further supported the expression of GrB in the emerging mo-DC population. This is the first report describing the expression of GrB protein in monocytes and mo-DC in response to various cytokine and TLR stimuli. Our results may open novel approaches to the improvement of mo-DC-related cellular vaccines based on the expression of certain proteases such as GrB." @default.
- W1465907849 created "2016-06-24" @default.
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- W1465907849 date "2013-05-01" @default.
- W1465907849 modified "2023-09-25" @default.
- W1465907849 title "Monocytes express the serine protease granzyme B - potential involvement in antigen processing and presentation. (P5033)" @default.
- W1465907849 doi "https://doi.org/10.4049/jimmunol.190.supp.110.17" @default.
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