Matches in SemOpenAlex for { <https://semopenalex.org/work/W1465941366> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1465941366 endingPage "9" @default.
- W1465941366 startingPage "211" @default.
- W1465941366 abstract "According to current teaching biogenic amines are released by exocytosis, i.e. by evacuation of amine storing vesicles or granules into the extracellular space. The release of transmitter amines is quantal, i.e. occurs in packs of transmitter molecules. These packs are assumed to be identical with vesicle contents, in other words, the smallest releasable quantum equals the amine content of one vesicle. However, there are experimental observations which do not fit in with this version of an exocytotic release theory. Observed quantitative discrepancies could be explained if the release mechanism allowed a fractional release of transmitter amine from several vesicles instead of the total evacuation of a few. The lack of adequate knowledge about the mechanisms of storage of biogenic amines within the vesicles has up til now rendered it difficult to envisage the machinery behind a fractional release of the amine content of a vesicle. In extensive in-vitro studies we have found that the matrices of amine storing granules (i.e. from mast cells, chromaffin cells and nerve terminals) show the properties of weak cation exchanger materials, carboxyl groups serving as amine binding ionic sites. When exposed to cations like sodium and potassium ions, the amines are released from their storage sites according to kinetics characteristic of weak cation exchangers. In vivo, amine release from cat adrenals on splanchnic nerve stimulation also occurs according to ion exchange kinetics. Histamine release from mast cells is considered to occur as the result of degranulation, i.e. the expulsion of histamine storing granules to the extracellular space, a typical example of exocytosis.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W1465941366 created "2016-06-24" @default.
- W1465941366 creator A5087089693 @default.
- W1465941366 date "1991-06-01" @default.
- W1465941366 modified "2023-10-09" @default.
- W1465941366 title "The molecular mechanism of nondegranulative release of biogenic amines." @default.
- W1465941366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1723635" @default.
- W1465941366 hasPublicationYear "1991" @default.
- W1465941366 type Work @default.
- W1465941366 sameAs 1465941366 @default.
- W1465941366 citedByCount "1" @default.
- W1465941366 crossrefType "journal-article" @default.
- W1465941366 hasAuthorship W1465941366A5087089693 @default.
- W1465941366 hasConcept C1122143 @default.
- W1465941366 hasConcept C121332964 @default.
- W1465941366 hasConcept C12554922 @default.
- W1465941366 hasConcept C130316041 @default.
- W1465941366 hasConcept C131779359 @default.
- W1465941366 hasConcept C148898269 @default.
- W1465941366 hasConcept C170493617 @default.
- W1465941366 hasConcept C175969161 @default.
- W1465941366 hasConcept C178790620 @default.
- W1465941366 hasConcept C185592680 @default.
- W1465941366 hasConcept C2776219046 @default.
- W1465941366 hasConcept C2778377861 @default.
- W1465941366 hasConcept C41625074 @default.
- W1465941366 hasConcept C49802076 @default.
- W1465941366 hasConcept C55493867 @default.
- W1465941366 hasConcept C62520636 @default.
- W1465941366 hasConcept C86803240 @default.
- W1465941366 hasConcept C98274493 @default.
- W1465941366 hasConceptScore W1465941366C1122143 @default.
- W1465941366 hasConceptScore W1465941366C121332964 @default.
- W1465941366 hasConceptScore W1465941366C12554922 @default.
- W1465941366 hasConceptScore W1465941366C130316041 @default.
- W1465941366 hasConceptScore W1465941366C131779359 @default.
- W1465941366 hasConceptScore W1465941366C148898269 @default.
- W1465941366 hasConceptScore W1465941366C170493617 @default.
- W1465941366 hasConceptScore W1465941366C175969161 @default.
- W1465941366 hasConceptScore W1465941366C178790620 @default.
- W1465941366 hasConceptScore W1465941366C185592680 @default.
- W1465941366 hasConceptScore W1465941366C2776219046 @default.
- W1465941366 hasConceptScore W1465941366C2778377861 @default.
- W1465941366 hasConceptScore W1465941366C41625074 @default.
- W1465941366 hasConceptScore W1465941366C49802076 @default.
- W1465941366 hasConceptScore W1465941366C55493867 @default.
- W1465941366 hasConceptScore W1465941366C62520636 @default.
- W1465941366 hasConceptScore W1465941366C86803240 @default.
- W1465941366 hasConceptScore W1465941366C98274493 @default.
- W1465941366 hasIssue "2" @default.
- W1465941366 hasLocation W14659413661 @default.
- W1465941366 hasOpenAccess W1465941366 @default.
- W1465941366 hasPrimaryLocation W14659413661 @default.
- W1465941366 hasRelatedWork W1465941366 @default.
- W1465941366 hasRelatedWork W1853145298 @default.
- W1465941366 hasRelatedWork W1984261175 @default.
- W1465941366 hasRelatedWork W2045306192 @default.
- W1465941366 hasRelatedWork W2071826283 @default.
- W1465941366 hasRelatedWork W2085669875 @default.
- W1465941366 hasRelatedWork W2087076539 @default.
- W1465941366 hasRelatedWork W2402489147 @default.
- W1465941366 hasRelatedWork W2471611987 @default.
- W1465941366 hasRelatedWork W2514476962 @default.
- W1465941366 hasVolume "42" @default.
- W1465941366 isParatext "false" @default.
- W1465941366 isRetracted "false" @default.
- W1465941366 magId "1465941366" @default.
- W1465941366 workType "article" @default.