Matches in SemOpenAlex for { <https://semopenalex.org/work/W1466068481> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1466068481 endingPage "51" @default.
- W1466068481 startingPage "51" @default.
- W1466068481 abstract "Present work aims to investigate functioning of the regulatory T-cells with suppressor activity in surgical sepsis. It has been shown that the septic patients with decreased T cell proliferation are characterized by enhanced relative contents of СD4+СD25+ lymphocytes, including СD4-CD25high. Moreover, a reverse correlation has been revealed between СD4+CD25+high and anti-CD3-induced proliferative response of mononuclear cells (MNC). Increased ratio of СD4+СD25+ cells is associated with arising suppressive activity of MNC, which is partially abrogated by addition of rIL-2. It should be noted that the depletion of CD25+ subpopulation is accompanied by increased T cell proliferation. Hence, a decrease in T cell proliferative activity in surgical sepsis is coupled with naturally occurring СD4+СD25+ regulatory T-cells (Trn). Furthermore, it has been demonstrated that the suppressive activity of MNCs in septic patients is mediated by soluble factors, in particular, IL-10. Indeed, septic patients are characterized by increased level of IL-10 production and enhanced number of CD4+IL-10+ T-cells. Addition of neutralizing anti-IL-10 antibody partially abrogated the suppressive activity of MNC supernatants. Thus, our study demonstrated that inducible regulatory T cells (Tr1) coupled to the naturally occurring СD4+СD25+ regulatory T-cells (Trn) actively contribute to genesis of immune pathology in sepsis." @default.
- W1466068481 created "2016-06-24" @default.
- W1466068481 creator A5017960968 @default.
- W1466068481 creator A5039927691 @default.
- W1466068481 creator A5040928701 @default.
- W1466068481 creator A5047490772 @default.
- W1466068481 creator A5056168940 @default.
- W1466068481 creator A5087383409 @default.
- W1466068481 date "2014-07-21" @default.
- W1466068481 modified "2023-10-05" @default.
- W1466068481 title "REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS" @default.
- W1466068481 doi "https://doi.org/10.15789/1563-0625-2006-1-51-60" @default.
- W1466068481 hasPublicationYear "2014" @default.
- W1466068481 type Work @default.
- W1466068481 sameAs 1466068481 @default.
- W1466068481 citedByCount "0" @default.
- W1466068481 crossrefType "journal-article" @default.
- W1466068481 hasAuthorship W1466068481A5017960968 @default.
- W1466068481 hasAuthorship W1466068481A5039927691 @default.
- W1466068481 hasAuthorship W1466068481A5040928701 @default.
- W1466068481 hasAuthorship W1466068481A5047490772 @default.
- W1466068481 hasAuthorship W1466068481A5056168940 @default.
- W1466068481 hasAuthorship W1466068481A5087383409 @default.
- W1466068481 hasBestOaLocation W14660684811 @default.
- W1466068481 hasConcept C104317684 @default.
- W1466068481 hasConcept C137061746 @default.
- W1466068481 hasConcept C179185449 @default.
- W1466068481 hasConcept C185592680 @default.
- W1466068481 hasConcept C202751555 @default.
- W1466068481 hasConcept C203014093 @default.
- W1466068481 hasConcept C2776090121 @default.
- W1466068481 hasConcept C2778296632 @default.
- W1466068481 hasConcept C2778384902 @default.
- W1466068481 hasConcept C502942594 @default.
- W1466068481 hasConcept C55493867 @default.
- W1466068481 hasConcept C62112901 @default.
- W1466068481 hasConcept C71924100 @default.
- W1466068481 hasConcept C79484868 @default.
- W1466068481 hasConcept C86803240 @default.
- W1466068481 hasConcept C8891405 @default.
- W1466068481 hasConcept C95444343 @default.
- W1466068481 hasConceptScore W1466068481C104317684 @default.
- W1466068481 hasConceptScore W1466068481C137061746 @default.
- W1466068481 hasConceptScore W1466068481C179185449 @default.
- W1466068481 hasConceptScore W1466068481C185592680 @default.
- W1466068481 hasConceptScore W1466068481C202751555 @default.
- W1466068481 hasConceptScore W1466068481C203014093 @default.
- W1466068481 hasConceptScore W1466068481C2776090121 @default.
- W1466068481 hasConceptScore W1466068481C2778296632 @default.
- W1466068481 hasConceptScore W1466068481C2778384902 @default.
- W1466068481 hasConceptScore W1466068481C502942594 @default.
- W1466068481 hasConceptScore W1466068481C55493867 @default.
- W1466068481 hasConceptScore W1466068481C62112901 @default.
- W1466068481 hasConceptScore W1466068481C71924100 @default.
- W1466068481 hasConceptScore W1466068481C79484868 @default.
- W1466068481 hasConceptScore W1466068481C86803240 @default.
- W1466068481 hasConceptScore W1466068481C8891405 @default.
- W1466068481 hasConceptScore W1466068481C95444343 @default.
- W1466068481 hasIssue "1" @default.
- W1466068481 hasLocation W14660684811 @default.
- W1466068481 hasLocation W14660684812 @default.
- W1466068481 hasOpenAccess W1466068481 @default.
- W1466068481 hasPrimaryLocation W14660684811 @default.
- W1466068481 hasRelatedWork W1454578587 @default.
- W1466068481 hasRelatedWork W2025778244 @default.
- W1466068481 hasRelatedWork W2059748759 @default.
- W1466068481 hasRelatedWork W2352803447 @default.
- W1466068481 hasRelatedWork W2398038232 @default.
- W1466068481 hasRelatedWork W2605096019 @default.
- W1466068481 hasRelatedWork W3031438654 @default.
- W1466068481 hasRelatedWork W3105314400 @default.
- W1466068481 hasRelatedWork W3112940496 @default.
- W1466068481 hasRelatedWork W2128850852 @default.
- W1466068481 hasVolume "8" @default.
- W1466068481 isParatext "false" @default.
- W1466068481 isRetracted "false" @default.
- W1466068481 magId "1466068481" @default.
- W1466068481 workType "article" @default.