FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W146648052> ?p ?o ?g. }

• W146648052 endingPage "400" @default.
• W146648052 startingPage "369" @default.
• W146648052 abstract "Behavioral discrimination procedures clearly demonstrate that nicotine elicits interoceptive stimulus effects in humans that are malleable by various pharmacological manipulations as well as by some behavioral manipulations. The parameters of nicotine discrimination and both chronic and acute factors that may alter discrimination behavior are addressed in this chapter, which emphasizes research by the author involving nicotine delivered by nasal spray. Human discrimination of nicotine is centrally mediated, as the central and peripheral nicotine antagonist mecamylamine blocks discrimination but the peripheral antagonist trimethaphan does not. The threshold dose for discrimination of nicotine via spray appears to be very low in smokers as well as nonsmokers. Because smoked tobacco delivers nicotine more rapidly than spray, the threshold dose of nicotine via smoking is probably even lower. In terms of individual differences, smokers may become tolerant to the discriminative stimulus effects of higher nicotine doses but not of low doses. Men may be more sensitive than women to nicotine's discriminative stimulus effects, consistent with other research suggesting that nicotine is more reinforcing in men than in women. Other potential individual differences in nicotine discrimination have not been clearly tested, but may include genetics, obesity, and dependence on other drugs. Acute environmental factors that alter nicotine discrimination include the specific training and testing conditions, pointing to the need for careful control over such conditions during research. Other factors, such as concurrent acute use of alcohol or caffeine, do not appear to alter nicotine discrimination, suggesting that changes in nicotine discrimination are not likely explanations for the association of smoking behavior with use of those drugs. Concurrent physical activity also does not appear to alter nicotine discrimination, indicating that results from studies of discrimination in subjects at quiet rest, the standard approach in this research, generalize well to discrimination in subjects engaged in various activities, as often occurs in the natural environment. Future research should more clearly examine the potential role of nicotine's discriminative stimulus effects in nicotine reinforcement and determine the generalizability of these findings to nicotine delivered by other means, particularly tobacco smoking.KeywordsNasal SprayDiscriminative Stimulus EffectDrug DiscriminationTraining DoseNicotine DoseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W146648052 created "2016-06-24" @default.
• W146648052 creator A5049888245 @default.
• W146648052 date "2009-01-31" @default.
• W146648052 modified "2023-10-15" @default.
• W146648052 title "Discriminative Stimulus Effects of Nicotine in Humans" @default.
• W146648052 cites W1569347416 @default.
• W146648052 cites W1701631897 @default.
• W146648052 cites W1946687472 @default.
• W146648052 cites W1966331187 @default.
• W146648052 cites W1966849908 @default.
• W146648052 cites W1967414446 @default.
• W146648052 cites W1967675530 @default.
• W146648052 cites W1967784272 @default.
• W146648052 cites W1969069774 @default.
• W146648052 cites W1970209789 @default.
• W146648052 cites W1973530603 @default.
• W146648052 cites W1977027245 @default.
• W146648052 cites W1977718302 @default.
• W146648052 cites W1979034154 @default.
• W146648052 cites W1984009591 @default.
• W146648052 cites W1986419433 @default.
• W146648052 cites W1986499504 @default.
• W146648052 cites W1989079947 @default.
• W146648052 cites W1989226291 @default.
• W146648052 cites W1991972892 @default.
• W146648052 cites W1992743097 @default.
• W146648052 cites W1995199423 @default.
• W146648052 cites W1997903037 @default.
• W146648052 cites W1998010690 @default.
• W146648052 cites W1998081378 @default.
• W146648052 cites W1999468298 @default.
• W146648052 cites W2000110014 @default.
• W146648052 cites W2003969360 @default.
• W146648052 cites W2012617532 @default.
• W146648052 cites W2015324885 @default.
• W146648052 cites W2016467106 @default.
• W146648052 cites W2020171179 @default.
• W146648052 cites W2026286877 @default.
• W146648052 cites W2028121707 @default.
• W146648052 cites W2034719708 @default.
• W146648052 cites W2034947167 @default.
• W146648052 cites W2035599334 @default.
• W146648052 cites W2038326871 @default.
• W146648052 cites W2039788998 @default.
• W146648052 cites W2044381447 @default.
• W146648052 cites W2046016582 @default.
• W146648052 cites W2047941155 @default.
• W146648052 cites W2048163423 @default.
• W146648052 cites W2048511472 @default.
• W146648052 cites W2053807540 @default.
• W146648052 cites W2055591504 @default.
• W146648052 cites W2057545278 @default.
• W146648052 cites W2061984900 @default.
• W146648052 cites W2061992054 @default.
• W146648052 cites W2064087046 @default.
• W146648052 cites W2064868186 @default.
• W146648052 cites W2067789877 @default.
• W146648052 cites W2069200516 @default.
• W146648052 cites W2069655769 @default.
• W146648052 cites W2072426002 @default.
• W146648052 cites W2077620252 @default.
• W146648052 cites W2081440578 @default.
• W146648052 cites W2082104563 @default.
• W146648052 cites W2082992993 @default.
• W146648052 cites W2083713935 @default.
• W146648052 cites W2084302047 @default.
• W146648052 cites W2085421334 @default.
• W146648052 cites W2091673195 @default.
• W146648052 cites W2092939280 @default.
• W146648052 cites W2094815737 @default.
• W146648052 cites W2106028379 @default.
• W146648052 cites W2106466862 @default.
• W146648052 cites W2107200746 @default.
• W146648052 cites W2112583815 @default.
• W146648052 cites W2122230158 @default.
• W146648052 cites W2126361388 @default.
• W146648052 cites W2128149876 @default.
• W146648052 cites W2144622867 @default.
• W146648052 cites W2161541522 @default.
• W146648052 cites W2164242610 @default.
• W146648052 cites W2170715261 @default.
• W146648052 cites W2312315095 @default.
• W146648052 cites W2325404800 @default.
• W146648052 cites W2916862519 @default.
• W146648052 cites W4231710557 @default.
• W146648052 cites W4237795005 @default.
• W146648052 cites W4246416283 @default.
• W146648052 cites W4246590748 @default.
• W146648052 cites W4251674458 @default.
• W146648052 cites W4252829977 @default.
• W146648052 doi "https://doi.org/10.1007/978-3-540-69248-5_13" @default.
• W146648052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19184656" @default.
• W146648052 hasPublicationYear "2009" @default.
• W146648052 type Work @default.
• W146648052 sameAs 146648052 @default.
• W146648052 citedByCount "18" @default.
• W146648052 countsByYear W1466480522012 @default.

• next