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- W1466702978 abstract "Summary A mouse model of localized candidosis in air‐filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5‐FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5‐FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5‐FC + Amph B was also tested against Candida albicans strains showing various degrees of 5‐FC‐resistance. A significant reduction in 5‐FC‐resistant mutants was seen after the treatment with the combination." @default.
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- W1466702978 date "1990-07-01" @default.
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- W1466702978 title "Antifungal combination therapy in localized candidosis" @default.
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- W1466702978 doi "https://doi.org/10.1111/myc.1990.33.7-8.353" @default.
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