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• W1467124535 abstract "Heteroclitic peptides are sequence variants of native peptide epitopes that stimulate Tcell responses superior to the native epitope. Since heteroclitic peptides enhance HIVspecificCD8⁺ T cell cytokine production, we investigated whether they reduce signsof HIV-specific CD8⁺ T cell exhaustion. Twenty-four variant peptides were generatedfrom reference human histocompatibility-linked leukocyte antigen (HLA)-A2-restricted peptide epitopes Nef 8391, Nef 135143, Gag 433440 and Gag7785 with conservative and semi-conservative amino acid substitutions at positions3, 5 and 7 or 3, 5 and 8 of Gag 433440. Variants that enhanced interferon-gamma(IFN-γ) and/or interleukin-2 (IL-2) production were tested for their effects onproliferation and programmed death-1 (PD-1) expression. Heteroclitic variantsenhanced HIV-specific CD8⁺ T cell proliferation by > 20% in 13/29 cases, inducedlower PD-1 expression by 15% - 50% in 10 cases, and by ≥ 50% in 3 cases. Thesedata indicate unique immunotherapeutic potential for heteroclitic peptides." @default.
• W1467124535 created "2016-06-24" @default.
• W1467124535 creator A5074812414 @default.
• W1467124535 date "2015-05-01" @default.
• W1467124535 modified "2023-09-24" @default.
• W1467124535 title "Heteroclitic human immunodeficiency virus peptides enhance HIV-specific CD8⁺ T cell proliferation and reduce PD-1 expression" @default.
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