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• W1467663189 endingPage "288" @default.
• W1467663189 startingPage "263" @default.
• W1467663189 abstract "This chapter discusses endogenous cardiac glycosides. The cardiac glycosides comprise a class of organic compounds derived largely from plant sources that have been used for millennia as therapeutic agents. Other clinically relevant cardiac glycosides are derived from the leaves of Digitalis lanata from which digitoxin and digoxin are derived, and from the seeds of Strophanthus gratus that contain gastrophanthin (ouabain). The molecular motif characteristic of the cardiac glycosides—a steroid nucleus containing an α,β-unsaturated lactone ring at the C17 position—are found in a large number of plants and a few toad species, usually acting as a venom or poison serving to alter the future behavior of predators. The chapter examines evidence purporting to support the existence of endogenous ligands for the cardiac glycoside binding site." @default.
• W1467663189 created "2016-06-24" @default.
• W1467663189 creator A5010883490 @default.
• W1467663189 creator A5019594950 @default.
• W1467663189 date "1994-01-01" @default.
• W1467663189 modified "2023-10-05" @default.
• W1467663189 title "Endogenous Cardiac Glycosides" @default.
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• W1467663189 doi "https://doi.org/10.1016/s1054-3589(08)60434-2" @default.
• W1467663189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8204503" @default.
• W1467663189 hasPublicationYear "1994" @default.
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