FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1467794802> ?p ?o ?g. }

• W1467794802 endingPage "44" @default.
• W1467794802 startingPage "638" @default.
• W1467794802 abstract "Familial adenomatous polyposis (FAP), a Mendelian disorder that includes familial polyposis coli (FPC) and Gardner syndrome (GS), has an autosomal dominant mode of inheritance. It is characterized by hundreds to thousands of adenomatous polyps that can progress to carcinoma of the colon, suggesting that the gene that harbors the FAP germ-line mutation may play an important role in the somatic genetic pathway to colon cancer. The defect responsible for FAP was recently mapped to the long arm of chromosome 5 by linkage between the FPC phenotype and a locus defined by DNA probe pC11p11 (D5S71), located at 5q21-22. Because an important next step in the paradigm for identification of a disease gene is to obtain a more precise localization, we isolated and mapped by linkage six additional polymorphic DNA markers in the FAP region. Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map. The analysis revealed no evidence of genetic heterogeneity between the two phenotypes, a question that had not been clearly resolved by the earlier studies. The new set of markers in the near vicinity of the FAP locus represents a further step toward isolation of the genetic defect and provides the opportunity for preclinical diagnosis of risk status for colon cancer among individuals in families that are segregating adenomatous polyposis." @default.
• W1467794802 created "2016-06-24" @default.
• W1467794802 creator A5008798496 @default.
• W1467794802 creator A5030998614 @default.
• W1467794802 creator A5044606171 @default.
• W1467794802 creator A5059664265 @default.
• W1467794802 creator A5061114231 @default.
• W1467794802 creator A5067592158 @default.
• W1467794802 creator A5079171795 @default.
• W1467794802 creator A5081216247 @default.
• W1467794802 creator A5081401174 @default.
• W1467794802 creator A5083981833 @default.
• W1467794802 date "1988-11-01" @default.
• W1467794802 modified "2023-09-25" @default.
• W1467794802 title "Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5." @default.
• W1467794802 cites W1549470101 @default.
• W1467794802 cites W1971209494 @default.
• W1467794802 cites W1972642770 @default.
• W1467794802 cites W1973800266 @default.
• W1467794802 cites W1978318259 @default.
• W1467794802 cites W1992682395 @default.
• W1467794802 cites W2002965287 @default.
• W1467794802 cites W2006874765 @default.
• W1467794802 cites W2014669590 @default.
• W1467794802 cites W2038685361 @default.
• W1467794802 cites W2040096357 @default.
• W1467794802 cites W2058403714 @default.
• W1467794802 cites W2070168194 @default.
• W1467794802 cites W2071697240 @default.
• W1467794802 cites W2092765135 @default.
• W1467794802 cites W2131164541 @default.
• W1467794802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1715544" @default.
• W1467794802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2903664" @default.
• W1467794802 hasPublicationYear "1988" @default.
• W1467794802 type Work @default.
• W1467794802 sameAs 1467794802 @default.
• W1467794802 citedByCount "100" @default.
• W1467794802 countsByYear W14677948022014 @default.
• W1467794802 countsByYear W14677948022016 @default.
• W1467794802 countsByYear W14677948022019 @default.
• W1467794802 crossrefType "journal-article" @default.
• W1467794802 hasAuthorship W1467794802A5008798496 @default.
• W1467794802 hasAuthorship W1467794802A5030998614 @default.
• W1467794802 hasAuthorship W1467794802A5044606171 @default.
• W1467794802 hasAuthorship W1467794802A5059664265 @default.
• W1467794802 hasAuthorship W1467794802A5061114231 @default.
• W1467794802 hasAuthorship W1467794802A5067592158 @default.
• W1467794802 hasAuthorship W1467794802A5079171795 @default.
• W1467794802 hasAuthorship W1467794802A5081216247 @default.
• W1467794802 hasAuthorship W1467794802A5081401174 @default.
• W1467794802 hasAuthorship W1467794802A5083981833 @default.
• W1467794802 hasConcept C104317684 @default.
• W1467794802 hasConcept C121608353 @default.
• W1467794802 hasConcept C122735190 @default.
• W1467794802 hasConcept C127716648 @default.
• W1467794802 hasConcept C13514818 @default.
• W1467794802 hasConcept C142870003 @default.
• W1467794802 hasConcept C175783326 @default.
• W1467794802 hasConcept C187296825 @default.
• W1467794802 hasConcept C190789776 @default.
• W1467794802 hasConcept C2778237340 @default.
• W1467794802 hasConcept C2780814781 @default.
• W1467794802 hasConcept C3020804800 @default.
• W1467794802 hasConcept C30481170 @default.
• W1467794802 hasConcept C501734568 @default.
• W1467794802 hasConcept C526805850 @default.
• W1467794802 hasConcept C54355233 @default.
• W1467794802 hasConcept C64618202 @default.
• W1467794802 hasConcept C84597430 @default.
• W1467794802 hasConcept C86803240 @default.
• W1467794802 hasConceptScore W1467794802C104317684 @default.
• W1467794802 hasConceptScore W1467794802C121608353 @default.
• W1467794802 hasConceptScore W1467794802C122735190 @default.
• W1467794802 hasConceptScore W1467794802C127716648 @default.
• W1467794802 hasConceptScore W1467794802C13514818 @default.
• W1467794802 hasConceptScore W1467794802C142870003 @default.
• W1467794802 hasConceptScore W1467794802C175783326 @default.
• W1467794802 hasConceptScore W1467794802C187296825 @default.
• W1467794802 hasConceptScore W1467794802C190789776 @default.
• W1467794802 hasConceptScore W1467794802C2778237340 @default.
• W1467794802 hasConceptScore W1467794802C2780814781 @default.
• W1467794802 hasConceptScore W1467794802C3020804800 @default.
• W1467794802 hasConceptScore W1467794802C30481170 @default.
• W1467794802 hasConceptScore W1467794802C501734568 @default.
• W1467794802 hasConceptScore W1467794802C526805850 @default.
• W1467794802 hasConceptScore W1467794802C54355233 @default.
• W1467794802 hasConceptScore W1467794802C64618202 @default.
• W1467794802 hasConceptScore W1467794802C84597430 @default.
• W1467794802 hasConceptScore W1467794802C86803240 @default.
• W1467794802 hasIssue "5" @default.
• W1467794802 hasLocation W14677948021 @default.
• W1467794802 hasOpenAccess W1467794802 @default.
• W1467794802 hasPrimaryLocation W14677948021 @default.
• W1467794802 hasRelatedWork W114113623 @default.
• W1467794802 hasRelatedWork W1467794802 @default.
• W1467794802 hasRelatedWork W1529998330 @default.
• W1467794802 hasRelatedWork W177226325 @default.
• W1467794802 hasRelatedWork W2001485763 @default.

• next