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- W1468304083 abstract "This chapter describes the studies conducted for atrial natriuretic factor (ANF) receptor assays. Cardiac atria are believed to play an important role in the regulation of extracellular fluid volume and electrolyte homeostasis. Distension of the atrial walls or an increase in intra-atrial pressure induces water and salt excretion. The ANF is synthesized in atrial cardiocytes and other tissues as a 126 amino acid prohormone. Its biological activity resides on the C-terminal part of the molecule, the 28 amino acid C-terminal peptide Ser99–Tyr126, which is released into the circulation. All the actions of ANF can be explained by its binding to specific receptors identified on plasma membranes of cells in a great variety of target tissues. Modern biochemical techniques and molecular biology have been used to identify, characterize, and clone ANF receptors with respect to molecular weight, composition, and regulation. Antireceptor antibodies could be a powerful tool in physiological studies to block receptors. Using molecular biology reagents, such as recombinant DNA probes, the number of genes that encode ANF receptors could be determined." @default.
- W1468304083 created "2016-06-24" @default.
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- W1468304083 date "1991-01-01" @default.
- W1468304083 modified "2023-09-27" @default.
- W1468304083 title "Atrial Natriuretic Factor Receptor Assays" @default.
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- W1468304083 doi "https://doi.org/10.1016/b978-0-12-185259-7.50033-8" @default.
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