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- W146866544 abstract "The studies reported here demonstrate how an unnoticed infection with bacterial “L-forms” (L for Lister Institute) may lead to erroneous diagnosis or interpretation in metabolic genetic disorders. Bacterial “L-forms” are bacterias which have lost their cell wall and have become resistent due to prolonged treatment with antibiotics. The morphology of the colonies compared to the mycoplasmas is very similar and can only be distinguished by an experienced microbiologist (Blenk, 1977). During our studies with HPRT mutant fibroblasts, we observed a sudden increase of HPRT activity, although mycoplasmas were absent. Increase of HPRT activity due to infection with mycoplasmas is known (Stanbridge et al., 1975). Special microbiological tests by Dr. Blenk revealed the presence of an infection with bacterial “L-forms” which could be traced back to a particular charge of fetal calf serum used by us. This observation prompted us further to characterize this contamination by using immunoprecipitation techniques and by studying its effects on incorporation of hypoxanthine and cell growth in selection media." @default.
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- W146866544 date "1980-01-01" @default.
- W146866544 modified "2023-09-23" @default.
- W146866544 title "High HPRT Activity in Fibroblasts from Patients with Lesch-Nyhan Syndrome Due to Bacterial “L-Form” Contamination" @default.
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- W146866544 doi "https://doi.org/10.1007/978-1-4615-9140-5_53" @default.
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