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• W1468761451 abstract "This chapter focuses principally on experimental infection of cattle since this model has many features that make it appealing as a model for the human disease. The experimental infection models of deer, possums, ferrets and badgers add to one’s understanding of tuberculosis and are compared to those in cattle. Models of bovine tuberculosis in cattle have been established to provide essential information for the development of new strategies of disease control, including improved methods for diagnosis and vaccination. In common with the human disease, it has been found that cell-mediated immune responses predominate in early bovine tuberculosis and that the development of an antibody response is often associated with advanced stages of infection. Use of an effective tuberculosis vaccine for cattle would be highly desirable in the countries that cannot control bovine tuberculosis by using the conventional “test and slaughter” strategy, whereby animals giving a positive skin reaction to tuberculin are identified as infected and slaughtered. The kinetics of immune responses to vaccination and subsequent challenge can be readily measured in cattle and provides insights into possible correlates of protection and disease. BCG vaccination sensitizes animals to tuberculin PPD-based diagnostic tests. Therefore, the development of differential diagnostic assays has concentrated on antigens whose genes are deleted or underexpressed in BCG but strongly expressed in virulent Mycobacterium bovis. The study of experimentally induced tuberculosis models in animals other than laboratory animals (mice, guinea pigs, and rabbits) can greatly expand one’s knowledge of tuberculosis." @default.
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• W1468761451 date "2005-01-01" @default.
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• W1468761451 title "Experimental Infection Models of Tuberculosis in Domestic and Wild Animals" @default.
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• W1468761451 doi "https://doi.org/10.1128/9781555817657.ch35" @default.
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