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- W1469417785 abstract "Publisher Summary This chapter presents some of the evidence from animal and clinical studies, implicating cholecystokinin (CCK)-peptides in the pathophysiology of schizophrenia. CCK pathways are extensively distributed throughout the CNS. CCK-immunoreactivity (CCK-IR) is co-localized with dopamine (DA) in some DA neurons projecting to limbic structures. The extent of the co-localization is species dependent. The co-existence of CCK and DA is of interest in view of the DA hypothesis of schizophrenia and the putative role of limbic dysfunction in the pathophysiology of this disorder. Several biochemicals, electrophysiological, and behavioral studies point to an interaction between CCK and DA. Some studies point to an inhibitory effect of CCK peptides on DA function, which would be compatible with a potential antischizophrenic action, others point to an enhancement. CCK peptides show a neuroleptic-like profile in several screening tests for neuroleptics but not in all studies. Cerebrospinal fluid (CSF) CCK-IR is described as being unchanged or decreased in schizophrenia. Autopsy studies have shown significant decreases, increases, or no change in brain CCK-IR in schizophrenia." @default.
- W1469417785 created "2016-06-24" @default.
- W1469417785 creator A5010047027 @default.
- W1469417785 creator A5010398559 @default.
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- W1469417785 date "1986-01-01" @default.
- W1469417785 modified "2023-09-27" @default.
- W1469417785 title "Cholecystokinin and Schizophrenia" @default.
- W1469417785 cites W1533195445 @default.
- W1469417785 cites W1545982428 @default.
- W1469417785 cites W1592065186 @default.
- W1469417785 cites W164162904 @default.
- W1469417785 cites W1780685243 @default.
- W1469417785 cites W1965737020 @default.
- W1469417785 cites W1966313666 @default.
- W1469417785 cites W1968946885 @default.
- W1469417785 cites W1971092191 @default.
- W1469417785 cites W1971483485 @default.
- W1469417785 cites W1974447282 @default.
- W1469417785 cites W1975429034 @default.
- W1469417785 cites W1975479266 @default.
- W1469417785 cites W1975733536 @default.
- W1469417785 cites W1976197643 @default.
- W1469417785 cites W1977803843 @default.
- W1469417785 cites W1979000449 @default.
- W1469417785 cites W1979603465 @default.
- W1469417785 cites W1980809655 @default.
- W1469417785 cites W1981537184 @default.
- W1469417785 cites W1987211745 @default.
- W1469417785 cites W1987754389 @default.
- W1469417785 cites W1988954356 @default.
- W1469417785 cites W1993089174 @default.
- W1469417785 cites W1993513457 @default.
- W1469417785 cites W1993606884 @default.
- W1469417785 cites W1995201487 @default.
- W1469417785 cites W1998021778 @default.
- W1469417785 cites W1999637957 @default.
- W1469417785 cites W1999768843 @default.
- W1469417785 cites W2002134809 @default.
- W1469417785 cites W2004304760 @default.
- W1469417785 cites W2004809019 @default.
- W1469417785 cites W2005339062 @default.
- W1469417785 cites W2005440761 @default.
- W1469417785 cites W2006772946 @default.
- W1469417785 cites W2007033110 @default.
- W1469417785 cites W2008698582 @default.
- W1469417785 cites W2009855715 @default.
- W1469417785 cites W2010856500 @default.
- W1469417785 cites W2011697056 @default.
- W1469417785 cites W2011960608 @default.
- W1469417785 cites W2012446170 @default.
- W1469417785 cites W2013400253 @default.
- W1469417785 cites W2015622448 @default.
- W1469417785 cites W2016670232 @default.
- W1469417785 cites W2018507547 @default.
- W1469417785 cites W2020195111 @default.
- W1469417785 cites W2020946796 @default.
- W1469417785 cites W2025444068 @default.
- W1469417785 cites W2025941877 @default.
- W1469417785 cites W2026846735 @default.
- W1469417785 cites W2028386029 @default.
- W1469417785 cites W2030152756 @default.
- W1469417785 cites W2031225260 @default.
- W1469417785 cites W2032709209 @default.
- W1469417785 cites W2033531502 @default.
- W1469417785 cites W2037022348 @default.
- W1469417785 cites W2037109665 @default.
- W1469417785 cites W2037283798 @default.
- W1469417785 cites W2039168152 @default.
- W1469417785 cites W2040416707 @default.
- W1469417785 cites W2041238811 @default.
- W1469417785 cites W2041340212 @default.
- W1469417785 cites W2044688205 @default.
- W1469417785 cites W2044774793 @default.
- W1469417785 cites W2046245471 @default.
- W1469417785 cites W2047412287 @default.
- W1469417785 cites W2048201690 @default.
- W1469417785 cites W2049666485 @default.
- W1469417785 cites W2051361832 @default.
- W1469417785 cites W2052094974 @default.
- W1469417785 cites W2052330864 @default.
- W1469417785 cites W2052717990 @default.
- W1469417785 cites W2055952173 @default.
- W1469417785 cites W2056859594 @default.
- W1469417785 cites W2061070426 @default.
- W1469417785 cites W2061847572 @default.
- W1469417785 cites W2066806129 @default.
- W1469417785 cites W2066944012 @default.
- W1469417785 cites W2067634010 @default.
- W1469417785 cites W2068221757 @default.
- W1469417785 cites W2068374219 @default.
- W1469417785 cites W2070370133 @default.
- W1469417785 cites W2071666492 @default.
- W1469417785 cites W2071966603 @default.
- W1469417785 cites W2072656326 @default.
- W1469417785 cites W2074909561 @default.
- W1469417785 cites W2075566384 @default.
- W1469417785 cites W2075886101 @default.