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- W1469872022 abstract "Pediatric myelodysplastic syndromes (MDS) are a group of rare clonal hematopoietic stem cell disorders characterized by varying degree of cytopenias, ineffective and dysplastic hematopoiesis, and the risk of leukemic transformation. The clinical, laboratory, and histologic presentation of pediatric MDS shares significant overlap with other inherited and acquired bone marrow failure (BMF) disorders. Given that the majority of pediatric patients with MDS present with a hypocellular bone marrow, the histopathologic diagnosis is challenging and usually requires ancillary molecular studies. While rapid advancements have been made in the field of adult MDS, the underlying genetics and pathophysiology of pediatric MDS are still poorly understood. The recent discovery of germline mutations in GATA2 leading to MDS suggests that some pediatric and young adult patients with MDS have an underlying genetic predisposition. Nevertheless, the molecular underpinnings remain poorly understood in most cases. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment option. Optimal timing of HSCT is not often straightforward, as some pediatric patients with low-grade MDS have an indolent disease course while others show rapid progression to advanced MDS and leukemia. Lastly, the classification of pediatric MDS has evolved over the years and is different from the terminology currently used in adult MDS. This review will focus on the current classification schemes of pediatric MDS and address clinical, laboratory, and pathologic features, as well as diagnostic criteria, genomic advances, and therapeutic options and prognosis." @default.
- W1469872022 created "2016-06-24" @default.
- W1469872022 creator A5038865667 @default.
- W1469872022 date "2015-07-26" @default.
- W1469872022 modified "2023-10-17" @default.
- W1469872022 title "Pediatric myelodysplastic syndromes" @default.
- W1469872022 cites W1004685331 @default.
- W1469872022 cites W138215329 @default.
- W1469872022 cites W1568156520 @default.
- W1469872022 cites W1912364782 @default.
- W1469872022 cites W196275111 @default.
- W1469872022 cites W1963690117 @default.
- W1469872022 cites W1973018894 @default.
- W1469872022 cites W1982046131 @default.
- W1469872022 cites W1985996991 @default.
- W1469872022 cites W1986016753 @default.
- W1469872022 cites W1987191562 @default.
- W1469872022 cites W1989711654 @default.
- W1469872022 cites W1990196345 @default.
- W1469872022 cites W1992286760 @default.
- W1469872022 cites W1996215491 @default.
- W1469872022 cites W1996404949 @default.
- W1469872022 cites W1999082722 @default.
- W1469872022 cites W1999580244 @default.
- W1469872022 cites W2001979268 @default.
- W1469872022 cites W2009202470 @default.
- W1469872022 cites W2010587952 @default.
- W1469872022 cites W2012170616 @default.
- W1469872022 cites W2016582822 @default.
- W1469872022 cites W2022154510 @default.
- W1469872022 cites W2029595590 @default.
- W1469872022 cites W2036269704 @default.
- W1469872022 cites W2045264636 @default.
- W1469872022 cites W2046678658 @default.
- W1469872022 cites W2047991220 @default.
- W1469872022 cites W2052778691 @default.
- W1469872022 cites W2053522990 @default.
- W1469872022 cites W2060073480 @default.
- W1469872022 cites W2061549613 @default.
- W1469872022 cites W2062068990 @default.
- W1469872022 cites W2062917916 @default.
- W1469872022 cites W2065033015 @default.
- W1469872022 cites W2065300348 @default.
- W1469872022 cites W2066403691 @default.
- W1469872022 cites W2066662718 @default.
- W1469872022 cites W2067953694 @default.
- W1469872022 cites W2070913348 @default.
- W1469872022 cites W2073889874 @default.
- W1469872022 cites W2078504783 @default.
- W1469872022 cites W2082552687 @default.
- W1469872022 cites W2086974150 @default.
- W1469872022 cites W2088584639 @default.
- W1469872022 cites W2089150270 @default.
- W1469872022 cites W2091158177 @default.
- W1469872022 cites W2097198718 @default.
- W1469872022 cites W2098258699 @default.
- W1469872022 cites W2099417620 @default.
- W1469872022 cites W2106078499 @default.
- W1469872022 cites W2106082819 @default.
- W1469872022 cites W2108249391 @default.
- W1469872022 cites W2109158516 @default.
- W1469872022 cites W2111661868 @default.
- W1469872022 cites W2118771330 @default.
- W1469872022 cites W2120306804 @default.
- W1469872022 cites W2121093592 @default.
- W1469872022 cites W2131106957 @default.
- W1469872022 cites W2135451940 @default.
- W1469872022 cites W2139410495 @default.
- W1469872022 cites W2140196635 @default.
- W1469872022 cites W2143247629 @default.
- W1469872022 cites W2144031672 @default.
- W1469872022 cites W2144892629 @default.
- W1469872022 cites W2147140533 @default.
- W1469872022 cites W2148216967 @default.
- W1469872022 cites W2149858388 @default.
- W1469872022 cites W2151723898 @default.
- W1469872022 cites W2152556705 @default.
- W1469872022 cites W2153657294 @default.
- W1469872022 cites W2160864702 @default.
- W1469872022 cites W2162675774 @default.
- W1469872022 cites W2165619252 @default.
- W1469872022 cites W2168813188 @default.
- W1469872022 cites W228303033 @default.
- W1469872022 cites W2322668491 @default.
- W1469872022 cites W4243763233 @default.
- W1469872022 cites W4246834630 @default.
- W1469872022 cites W97477215 @default.
- W1469872022 cites W2156786139 @default.
- W1469872022 doi "https://doi.org/10.1007/s12308-015-0253-4" @default.
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