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• W1469890906 abstract "Chemotherapies targeting deoxynucleotide triphosphate synthesis are of high medical interest in the treatment of gynecologic malignancies. In this article, we focus on targeted inhibitors of ribonucleotide reductase, an enzyme in charge of ribonucleotide reduction to their corresponding deoxyribonucleotide to be used as the building blocks of DNA. We also discuss human clinical trials have utilized ribonucleotide reductase subunit-specific inhibitors, particularly trials for women with cervical cancer." @default.
• W1469890906 created "2016-06-24" @default.
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• W1469890906 date "2012-01-01" @default.
• W1469890906 modified "2023-10-18" @default.
• W1469890906 title "Molecular Strategies of Deoxynucleotide Triphosphate Supply Inhibition Used in the Treatment of Gynecologic Malignancies" @default.
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• W1469890906 doi "https://doi.org/10.4172/2161-0932.s4-001" @default.
• W1469890906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4226428" @default.
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